Neutrophils have always been considered as uncomplicated front-line troopers of the innate
immune system equipped with limited proinflammatory duties. Yet recently, the role of the …

How does the coagulation protease thrombin regulate cellular behaviour? The protease-
activated receptors (PARs) provide one answer. In concert with the coagulation cascade …

Somlyo, Andrew P., and Avril V. Somlyo. Ca2+ Sensitivity of Smooth Muscle and Nonmuscle
Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase. Physiol Rev 83 …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Intercellular junctions mediate adhesion and communication between adjoining endothelial
and epithelial cells. In the endothelium, junctional complexes comprise tight junctions …

Severe sepsis, defined as sepsis with acute organ dysfunction, is associated with high
morbidity and mortality rates. The development of novel therapies for sepsis is critically …

Junctional structures maintain the integrity of the endothelium. Recent studies have shown
that, as well as promoting cell–cell adhesion, junctions might transfer intracellular signals …

Vascular endothelial (VE)-cadherin is a strictly endothelial specific adhesion molecule
located at junctions between endothelial cells. In analogy of the role of E-cadherin as major …

The coagulation cascade and protease‐activated receptors (PARs) together provide an
elegant mechanism that links mechanical information in the form of tissue injury to cellular …

Abstract Ossovskaya, Valeria S., and Nigel W. Bunnett. Protease-Activated Receptors:
Contribution to Physiology and Disease. Physiol Rev 84: 579–621, 2004; 10.1152/physrev …