The neural crest is a transient, multipotent population of cells that arises at the border of the
developing nervous system. After closure of the neural tube, these cells undergo an …

The neural crest is a fascinating embryonic population unique to vertebrates that is endowed
with remarkable differentiation capacity. Thought to originate from ectodermal tissue, neural …

Precise control of developmental processes is encoded in the genome in the form of gene
regulatory networks (GRNs). Such multi-factorial systems are difficult to decode in …

Embryonic stem cells (ESCs) can adopt lineage-specific gene-expression programs by
stepwise exposure to defined factors, resulting in the generation of functional cell types. Bulk …

The neural crest is a uniquely vertebrate cell type and has been well studied in a number of
model systems. Zebrafish, Xenopus and chick embryos largely show consistent …

The neural crest (NC) cells and cranial placodes are two ectoderm-derived innovations in
vertebrates that led to the acquisition of a complex head structure required for a predatory …

The neural crest is a transient embryonic tissue that gives rise to a multitude of derivatives in
an axially restricted manner. An in vitro counterpart to neural crest can be derived from …

Cell fate commitment is controlled by cis-regulatory elements often located in remote regions
of the genome. To examine the role of long-range DNA interactions in early development …

The process of cell fate commitment involves sequential changes in the gene expression
profiles of embryonic progenitors. This is exemplified in the development of the neural crest …

The extracellular signal-regulated kinase (ERK1/2) pathway is essential in embryonic
development. The scaffold protein Shoc2 is a critical modulator of ERK1/2 signals, and …