Mesenchymal stem cells for neurological disorders

A Andrzejewska, S Dabrowska, B Lukomska… - Advanced …, 2021 - Wiley Online Library
Neurological disorders are becoming a growing burden as society ages, and there is a
compelling need to address this spiraling problem. Stem cell‐based regenerative medicine …

Mesenchymal stromal cell therapies for neurodegenerative diseases

NP Staff, DT Jones, W Singer - Mayo Clinic Proceedings, 2019 - Elsevier
Mesenchymal stromal cells are multipotent cells that are being used to treat a variety of
medical conditions. Over the past decade, there has been considerable excitement about …

Mesenchymal stromal cells (MSCs) for neurodegenerative disease: a promising frontier

A Shariati, R Nemati, Y Sadeghipour… - European journal of cell …, 2020 - Elsevier
Neurodegenerative disorders are a variety of diseases including Alzheimer's (AD),
Parkinson's (PD), and Huntington's diseases (HD), multiple sclerosis (MS) and amyotrophic …

A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse

MS Gee, SH Son, SH Jeon, J Do, N Kim, YJ Ju… - Alzheimer's research & …, 2020 - Springer
Background Chronic neuroinflammation, aggressive amyloid beta (Aβ) deposition, neuronal
cell loss, and cognitive impairment are pathological presentations of Alzheimer's disease …

Effect of systemic transplantation of bone marrow‐derived mesenchymal stem cells on neuropathology markers in APP/PS 1 Alzheimer mice

Y Naaldijk, C Jaeger, C Fabian… - Neuropathology and …, 2017 - Wiley Online Library
Aims Mesenchymal stem cells (MSC) have recently attracted interest as a potential basis for
a cell‐based therapy of AD. We investigated the putative immune‐modulatory effects in …

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease

JY Lee, SH Han, MH Park, B Baek, IS Song… - Nature …, 2018 - nature.com
Although many reports have revealed the importance of defective microglia-mediated
amyloid β phagocytosis in Alzheimer's disease (AD), the underlying mechanism remains to …

Stem cell therapy for Alzheimer's disease: An overview of experimental models and reality

C Qin, K Wang, L Zhang, L Bai - Animal models and …, 2022 - Wiley Online Library
Alzheimer's disease (AD) is a neurodegenerative disorder. The pathology of AD is
characterized by extracellular amyloid beta (Aβ) plaques, neurofibrillary tangles composed …

Placenta-derived mesenchymal stem cells improve memory dysfunction in an Aβ1–42-infused mouse model of Alzheimer's disease

HM Yun, HS Kim, KR Park, JM Shin, AR Kang… - Cell death & …, 2013 - nature.com
Mesenchymal stem cells (MSCs) promote functional recoveries in pathological experimental
models of central nervous system (CNS) and are currently being tested in clinical trials for …

The functional mechanism of bone marrow-derived mesenchymal stem cells in the treatment of animal models with Alzheimer's disease: crosstalk between autophagy …

C Qin, L Bai, Y Li, K Wang - Stem cell research & therapy, 2022 - Springer
The transplantation of bone marrow-derived mesenchymal stem cells (BMMSCs) alleviates
neuropathology and improves cognitive deficits in animal models with Alzheimer's disease …

Clinical PET imaging of microglial activation: implications for microglial therapeutics in Alzheimer's disease

Z Shen, X Bao, R Wang - Frontiers in aging neuroscience, 2018 - frontiersin.org
In addition to extracellular β-amyloid plaques and intracellular neurofibrillary tangles,
neuroinflammation has been identified as a key pathological characteristic of Alzheimer's …