Lentiviral vectors (LVs) are potent tools for the delivery of genes of interest into mammalian
cells and are now commonly utilised within the growing field of cell and gene therapy for the …

The main focus of this work was the improvement of the stability of the current PPRV
vaccine. First, new formulations based on the Tris buffer were tested, with and without the …

The use of retroviral vectors for gene therapy applications demands high titer preparations
and stringent quality standards. However, the manufacturing of these vectors still represents …

Background aims Chimeric antigen receptor (CAR) T-cell products are commonly generated
using lentiviral vector (LV) transduction. Optimal final formulation buffer (FFB) supporting LV …

Sheep pox virus initially adapted to replicate in primary lamb kidney cells was adapted to
Vero cells by serial passages in monolayer cultures. After nine passages the virus was able …

The manufacture of enveloped virus, particularly retroviral (RV) and lentiviral (LV) vectors,
faces the challenge of low titers that are aggravated under serum deprivation culture …

Lentiviral vectors (LV) are potent tools in delivering genetic information for vac-cines and
therapeutic benefits. Bioprocessing of LV remains challenging, with vec-tor generation …

Retroviral vectors are presently amongst the most widely used vectors in gene therapy
clinical trials to target pathologies of different origins, such as cancers, genetic diseases or …

Retrovirus (RV) based biopharmaceuticals comprise several valuable bioproducts such as
gene therapy vectors, recombinant vaccines and replicative-competent particles for oncolytic …

The development of serum-free processes is crucial for the safety and standardization of
biopharmaceuticals production. However, serum replacement is still a challenge in several …