Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds

HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …

The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation

J Haerinck, S Goossens, G Berx - Nature Reviews Genetics, 2023 - nature.com
Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy

Y Lu, YT Chan, HY Tan, S Li, N Wang, Y Feng - Molecular cancer, 2020 - Springer
Epigenetics is dynamic and heritable modifications to the genome that occur independently
of DNA sequence. It requires interactions cohesively with various enzymes and other …

The miR-200 family of microRNAs: fine tuners of epithelial-mesenchymal transition and circulating cancer biomarkers

I Cavallari, F Ciccarese, E Sharova, L Urso… - Cancers, 2021 - mdpi.com
Simple Summary MicroRNAs (miRNAs) are small RNA molecules that regulate gene
expression by blocking translation or inducing degradation of specific gene transcripts. The …

Regulatory networks defining EMT during cancer initiation and progression

BD Craene, G Berx - Nature Reviews Cancer, 2013 - nature.com
Epithelial to mesenchymal transition (EMT) is essential for driving plasticity during
development, but is an unintentional behaviour of cells during cancer progression. The EMT …

The epigenetics of epithelial-mesenchymal plasticity in cancer

WL Tam, RA Weinberg - Nature medicine, 2013 - nature.com
During the course of malignant cancer progression, neoplastic cells undergo dynamic and
reversible transitions between multiple phenotypic states, the extremes of which are defined …

MicroRNAs in cancer

G Di Leva, M Garofalo, CM Croce - Annual Review of Pathology …, 2014 - annualreviews.org
MicroRNAs (miRNAs) are small noncoding RNAs that typically inhibit the translation and
stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such …

MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis

K Hur, Y Toiyama, M Takahashi, F Balaguer… - Gut, 2013 - gut.bmj.com
Objective Distant metastasis is the major cause of cancer-related death in patients with
colorectal cancer (CRC). Although the microRNA-200 (miR-200) family is a crucial inhibitor …

[HTML][HTML] MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling

SJ Song, L Poliseno, MS Song, U Ala, K Webster, C Ng… - Cell, 2013 - cell.com
Tumor cells metastasize to distant organs through genetic and epigenetic alterations,
including changes in microRNA (miR) expression. Here we find miR-22 triggers epithelial …

MicroRNAs in the p53 network: micromanagement of tumour suppression

H Hermeking - Nature reviews cancer, 2012 - nature.com
In recent years, microRNAs (miRNAs) have been identified as mediators of tumour
suppression and stress responses exerted by the p53 tumour suppressor. p53-regulated …