The fibrous cap is formed by smooth muscle cells that accumulate beneath the plaque
endothelium. Cap rupture is the main cause of coronary thrombosis, leading to infarction …

Atherosclerotic plaque results from a complex interplay between lipid deposition,
inflammatory changes, cell migration and arterial wall injury. Over the past two decades …

Background Few studies explored the effect of the combination of glucose sodium-
cotransporter-2 inhibitors (SGLT-2i) and glucagon-like peptide-1 receptor agonists (GLP …

Sodium-glucose cotransporter-2 inhibitors (SGLT2is) are widely used in cardiology and are
effective in treating acute coronary syndrome (ACS). Their effects on unstable plaque in …

Background Pharmacological post-MI treatment is routinely initiated at intensive/cardiac
care units. However, solid evidence for an early start of these therapies is only available for …

Abstract Background/Objectives To date, evidence regarding the protective roles of the
Mediterranean-Dietary Approaches to Stop Hypertension Intervention for …

Inflammation plays an essential role and is a common feature in the pathogenesis of many
chronic diseases. The exact mechanisms through which sodium-glucose cotransporter-2 …

Background The gut microbiota differs between patients with coronary artery disease (CAD)
and healthy controls; however, it currently remains unclear whether these differences exist …

Dyslipidaemia plays a prominent role in the genesis of atherosclerotic plaque and the
increased cardiovascular risk in diabetes. Macrophages readily take up atherogenic …

Diabetes mellitus (DM) is a multi-factorial metabolic disease that affects approximately 462
million individuals, corresponding to 6.28% of the world's population (4.4% of those aged 15 …