Prefrontal cortex development in health and disease: lessons from rodents and humans
M Chini, IL Hanganu-Opatz - Trends in neurosciences, 2021 - cell.com
The role of the prefrontal cortex (PFC) takes center stage among unanswered questions in
modern neuroscience. The PFC has a Janus-faced nature: it enables sophisticated cognitive …
modern neuroscience. The PFC has a Janus-faced nature: it enables sophisticated cognitive …
One is not enough: understanding and modeling polysubstance use
EA Crummy, TJ O'Neal, BM Baskin… - Frontiers in …, 2020 - frontiersin.org
Substance use disorder (SUD) is a chronic, relapsing disease with a highly multifaceted
pathology that includes (but is not limited to) sensitivity to drug-associated cues, negative …
pathology that includes (but is not limited to) sensitivity to drug-associated cues, negative …
Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity
Variation in an animal's behavioral state is linked to fluctuations in brain activity and
cognitive ability. In the neocortex, state-dependent circuit dynamics may reflect …
cognitive ability. In the neocortex, state-dependent circuit dynamics may reflect …
Mechanisms underlying gain modulation in the cortex
KA Ferguson, JA Cardin - Nature Reviews Neuroscience, 2020 - nature.com
Cortical gain regulation allows neurons to respond adaptively to changing inputs. Neural
gain is modulated by internal and external influences, including attentional and arousal …
gain is modulated by internal and external influences, including attentional and arousal …
Inhibitory interneurons regulate temporal precision and correlations in cortical circuits
JA Cardin - Trends in neurosciences, 2018 - cell.com
GABAergic interneurons, which are highly diverse, have long been thought to contribute to
the timing of neural activity as well as to the generation and shaping of brain rhythms …
the timing of neural activity as well as to the generation and shaping of brain rhythms …
[HTML][HTML] Inhibitory control of the excitatory/inhibitory balance in psychiatric disorders
Neuronal networks consist of different types of neurons that all play their own role in order to
maintain proper network function. The two main types of neurons segregate in excitatory and …
maintain proper network function. The two main types of neurons segregate in excitatory and …
Strong inhibitory signaling underlies stable temporal dynamics and working memory in spiking neural networks
R Kim, TJ Sejnowski - Nature neuroscience, 2021 - nature.com
Cortical neurons process information on multiple timescales, and areas important for
working memory (WM) contain neurons capable of integrating information over a long …
working memory (WM) contain neurons capable of integrating information over a long …
Inhibitory circuit gating of auditory critical-period plasticity
AE Takesian, LJ Bogart, JW Lichtman… - Nature neuroscience, 2018 - nature.com
Cortical sensory maps are remodeled during early life to adapt to the surrounding
environment. Both sensory and contextual signals are important for induction of this …
environment. Both sensory and contextual signals are important for induction of this …
Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment
Z Szadai, HJ Pi, Q Chevy, K Ócsai, DF Albeanu… - Elife, 2022 - elifesciences.org
Neocortex is classically divided into distinct areas, each specializing in different function, but
all could benefit from reinforcement feedback to inform and update local processing. Yet it …
all could benefit from reinforcement feedback to inform and update local processing. Yet it …
A central extended amygdala circuit that modulates anxiety
S Ahrens, MV Wu, A Furlan, GR Hwang… - Journal of …, 2018 - Soc Neuroscience
Both the amygdala and the bed nucleus of the stria terminalis (BNST) have been implicated
in maladaptive anxiety characteristics of anxiety disorders. However, the underlying circuit …
in maladaptive anxiety characteristics of anxiety disorders. However, the underlying circuit …