RASSF1A (Ras association domain family 1 isoform A) is a recently discovered tumor
suppressor whose inactivation is implicated in the development of many human cancers …

In recent years, the list of tumor suppressor genes (or candidate TSG) that are inactivated
frequently by epigenetic events rather than classic mutation/deletion events has been …

Long noncoding RNA (lncRNA) is a kind of RNAi molecule composed of hundreds to
thousands of nucleotides. There are several major types of functional lncRNAs which …

Tumour suppressor gene inactivation is critical to the pathogenesis of cancers; such loss of
function may be mediated by irreversible processes such as gene deletion or mutation …

Aberrant promoter hypermethylation of several known or putative tumor suppressor genes
occurs frequently during the pathogenesis of human cancers and is a promising marker for …

Loss of heterozygosity of the small arm of chromosome 3 is one of the most common
alterations in human cancer. Most notably, a segment in 3p21. 3 is frequently lost in lung …

AIM: To establish the methylation profile of the promoter CpG islands of 31 genes that might
play etiological roles in colon carcinogenesis. METHODS: The methylation specific PCR in …

The human Ras association domain family 1 (RASSF1) gene is located at 3p21. 3 in an area
that is believed to harbor at least one important tumor suppressor gene. The two major …

Wilms' tumor, or nephroblastoma, is the most common pediatric renal cancer. The tumors
morphologically resemble embryonic kidneys with a disrupted architecture and are …

The RAS association domain family 1A (RASSF1A) gene is silenced by DNA methylation in
over 50% of all solid tumors of different histological types. However, the biochemical function …