Macrophages are the key inflammatory cell type involved in all stages of atherosclerosis
development and progression, as demonstrated by numerous studies. Correspondingly …

Platelets, anucleate blood components, represent the major cell type involved in the
regulation of hemostasis and thrombosis. In addition to performing haemostatic roles …

Atherosclerosis is a disease of chronic inflammation. We investigated the roles of the
cytokines IL-4 and IL-13, the classical activators of STAT6, in the resolution of …

Objective: Plaque necrosis is a key feature of defective resolution in atherosclerosis. Recent
evidence suggests that necroptosis promotes plaque necrosis; therefore, we sought to …

Alzheimer's disease (AD) and related dementias (ADRD) collectively affect a significant
portion of the aging population worldwide. The pathological progression of AD involves not …

Both platelets and the liver play important roles in the processes of coagulation and innate
immunity. Platelet responses at the site of an injury are rapid; their immediate activation and …

Platelets play a key role in the development, progression and resolution of the inflammatory
response during sterile inflammation and infection, although the mechanism is not well …

Platelets are anucleate blood cells derived from megakaryocytes. They link the fundamental
functions of hemostasis, inflammation and host defense. They undergo intracellular calcium …

Both platelets and the liver play important roles in the processes of coagulation and innate
immunity. Platelet responses at the site of an injury are rapid; their immediate activation and …

Endocan is an endothelial cell-specific proteoglycan that contributes to vascular dysfunction
by impairing endothelial function and inducing vascular smooth muscle cell migration …