Bile formation is an important function of the liver. Bile salts are a major constituent of bile
and are secreted by hepatocytes into bile and delivered into the small intestine, where they …

The vectorial secretion of bile salts from blood into bile is a major driving force for bile
formation. The basolateral hepatocyte membrane extracts bile salts from sinusoidal blood …

Biliary excretion of xenobiotics is a complex process involving uptake into liver cells,
intracellular sequestration and/or biotransformation, and transport into bile. A description of …

Many of the foreign compounds that enter the body, including environmental xenobiotics,
drugs, and plant or animal toxins, are organic anions and cations. In addition, both foreign …

One of the main functions of the liver, the formation of bile, involves the vectorial transport of
compounds such as bile salts, phospholipids, cholesterol and other organic compounds …

We are studying the mechanism underlying chemosensitization of anticancer‐drug
cytotoxicity in wild‐type and multidrug‐resistant (MDR) mammalian cells. We show here that …

The SLC10 family represents seven genes containing 1–12 exons that encode proteins in
humans with sequence lengths of 348–477 amino acids. Although termed solute carriers …

Mutations in the FIC1 gene constitute the molecular defect in familial intrahepatic cholestasis
I (Fic1 [Byler's disease]) and benign recurrent intrahepatic cholestasis. This report describes …

The secretion of bile by the liver is primarily determined by the ability of the hepatocyte to
transport bile acids into the bile canaliculus. A carrier-mediated process for the transport of …

Introduction Secretion of bile is a unique function of the liver and represents one of its major
activities. Bile is both a secretory and an excretory fluid and, as such, its composition is …