The water channel aquaporin-2 (AQP2), expressed in the kidney collecting ducts, plays a
pivotal role in maintaining body water balance. The channel is regulated by the peptide …

Any aspect of cell activity is regulated by extracellular signals that are recognized, decoded,
and transduced inside the cell via different classes of plasma membrane receptors. 1À3 G …

Vasopressin (VP) and oxytocin (OT) are cyclic neuropeptides that regulate fundamental
physiological functions via four G protein-coupled receptors, V1aR, V1bR, V2R, and OTR …

Abstract Isoliquiritigenin (= 4, 2′, 4′-Trihydroxychalcone)(ILG) is a major constituent of the
Glycyrrhizae Rhizoma that has significant neuroprotective functions. In the present study, we …

The urine concentrating function of the kidney is essential to maintain the water homeostasis
of the human body. It is mainly regulated by the arginine-vasopressin (AVP), which targets …

Background: Desmopressin (dDAVP), a synthetic nonapeptide derivative of arginine
vasopressin, is a safe antidiuretic and hemostatic compound that acts as a selective agonist …

Aims Non-peptide ligands of oxytocin receptor (OTR) have promising potentialities as
therapeutic agents with improved pharmacological properties. WAY-267,464 is a non …

Abstract Starting from the 2.8-Å resolution x-ray structure of bovine rhodopsin, three-
dimensional molecular models of the complexes between arginine vasopressin and two …

This study presents the 3D model of the complex between the anaphylatoxin C5a and its
specific receptor, C5aR. This is the first 3D model of a G-protein-coupled receptor (GPCR) …

We describe the synthesis, pharmacological properties, and structures of antidiuretic
agonists, arginine vasopressin (AVP) and [d-Arg 8]-vasopressin (DAVP), and their inverso …