Next-generation approaches to understand and combat the antibiotic resistome

TS Crofts, AJ Gasparrini, G Dantas - Nature Reviews Microbiology, 2017 - nature.com
Antibiotic resistance is a natural feature of diverse microbial ecosystems. Although recent
studies of the antibiotic resistome have highlighted barriers to the horizontal transfer of …

Antimicrobial resistance in Mycobacterium tuberculosis: mechanistic and evolutionary perspectives

SM Gygli, S Borrell, A Trauner… - FEMS microbiology …, 2017 - academic.oup.com
Antibiotic-resistant Mycobacterium tuberculosis strains are threatening progress in
containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically …

[HTML][HTML] Antibiotic resistance in Vibrio cholerae: understanding the ecology of resistance genes and mechanisms

B Das, J Verma, P Kumar, A Ghosh, T Ramamurthy - Vaccine, 2020 - Elsevier
The unique genetic makeup and remarkable competency of Vibrio cholerae are the key
factors that help the cholera pathogen adapt rapidly to adverse environmental conditions …

The evolution of antibiotic resistance is associated with collateral drug phenotypes in Mycobacterium tuberculosis

NJE Waller, CY Cheung, GM Cook… - Nature …, 2023 - nature.com
The increasing incidence of drug resistance in Mycobacterium tuberculosis has diminished
the efficacy of almost all available antibiotics, complicating efforts to combat the spread of …

Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains

HMA Hameed, MM Islam, C Chhotaray… - Frontiers in cellular …, 2018 - frontiersin.org
Tuberculosis (TB) is a formidable infectious disease that remains a major cause of death
worldwide today. Escalating application of genomic techniques has expedited the …

Genomic insights into tuberculosis

JE Galagan - Nature Reviews Genetics, 2014 - nature.com
Prevalent since pre-history, human tuberculosis—caused by the pathogen Mycobacterium
tuberculosis—remains a major source of death worldwide. Moreover, increasing drug …

Molecular diagnosis of drug-resistant tuberculosis; a literature review

TNA Nguyen, V Anton-Le Berre, AL Bañuls… - Frontiers in …, 2019 - frontiersin.org
Drug-resistant tuberculosis is a global health problem that hinders the progress of
tuberculosis eradication programs. Accurate and early detection of drug-resistant …

Totally drug‐resistant tuberculosis and adjunct therapies

SK Parida, R Axelsson‐Robertson… - Journal of internal …, 2015 - Wiley Online Library
The first cases of totally drug‐resistant (TDR) tuberculosis (TB) were reported in Italy 10
years ago; more recently, cases have also been reported in Iran, India and South Africa …

Profiling pretomanid as a therapeutic option for TB infection: evidence to date

SL Stancil, F Mirzayev… - Drug Design …, 2021 - Taylor & Francis
Tuberculosis (TB) is the most deadly infectious disease globally. Although most individuals
achieve a cure, a substantial portion develop multi-drug resistant TB which is exceedingly …

[HTML][HTML] Strategies for lipid-based nanocomposites with potential activity against Mycobacterium tuberculosis: Microbial resistance challenge and drug delivery trends

AC Hatae, CA Roque-Borda, FR Pavan - OpenNano, 2023 - Elsevier
Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis, stands as an
immensely devastating and persistently relevant pathogen, claiming the lives of millions …