Natural products of pentacyclic triterpenoids: from discovery to heterologous biosynthesis

Y Li, J Wang, L Li, W Song, M Li, X Hua… - Natural Product …, 2023 - pubs.rsc.org
Covering: up to 2022 Pentacyclic triterpenoids are important natural bioactive substances
that are widely present in plants and fungi. They have significant medicinal efficacy, play an …

Oleanolic acid and its derivatives: biological activities and therapeutic potential in chronic diseases

TB Ayeleso, MG Matumba, E Mukwevho - Molecules, 2017 - mdpi.com
The increasing demand for natural products as an alternative therapy for chronic diseases
has encouraged research into the pharmacological importance of bioactive compounds from …

Anti-viral triterpenes: a review

P Darshani, S Sen Sarma, AK Srivastava… - Phytochemistry …, 2022 - Springer
Triterpenes are naturally occurring derivatives biosynthesized following the isoprene rule of
Ruzicka. The triterpenes have been reported to possess a wide range of therapeutic …

[HTML][HTML] Anticancer activity of oleanolic acid and its derivatives: Recent advances in evidence, target profiling and mechanisms of action

ZY Tang, Y Li, YT Tang, XD Ma, ZY Tang - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Abstract Oleanolic acid (OA, 3 β-hydroxyoleanolic acid-12-en-28-oic acid) is a pentacyclic
triterpenoid present in many plants. As a new framework for development of semi synthetic …

Myocarditis in humans and in experimental animal models

P Błyszczuk - Frontiers in cardiovascular medicine, 2019 - frontiersin.org
Myocarditis is defined as an inflammation of the cardiac muscle. In humans, various
infectious and non-infectious triggers induce myocarditis with a broad spectrum of …

Immunomodulatory properties of triterpenes

G Renda, İ Gökkaya, D Şöhretoğlu - Phytochemistry Reviews, 2022 - Springer
The immune system is one of the main defence mechanisms of the human body.
Inadequacy of this system or immunodeficiency results in increased risk of infections and …

Ursolic acid and oleanolic acid: pentacyclic terpenoids with promising anti-inflammatory activities

D Kashyap, A Sharma, H S. Tuli, S Punia… - Recent Patents on …, 2016 - benthamdirect.com
Background: Plant derived products are not only served as dietary components but also
used to treat and prevent the inflammatory associated diseases like cancer. Among the …

[HTML][HTML] Prophylactic and therapeutic roles of oleanolic acid and its derivatives in several diseases

A Sen - World Journal of Clinical Cases, 2020 - ncbi.nlm.nih.gov
Oleanolic acid (OA) and its derivatives are widely found in diverse plants and are naturally
effective pentacyclic triterpenoid compounds with broad prophylactic and therapeutic roles …

The CXCL10/CXCR3 axis and cardiac inflammation: implications for immunotherapy to treat infectious and noninfectious diseases of the heart

R Altara, Z Mallat, GW Booz… - Journal of immunology …, 2016 - Wiley Online Library
Accumulating evidence reveals involvement of T lymphocytes and adaptive immunity in the
chronic inflammation associated with infectious and noninfectious diseases of the heart …

[PDF][PDF] Biologically active triterpenoids and their cardioprotective and anti-inflammatory effects

N Han, M Bakovic - J Bioanal Biomed S, 2015 - pdfs.semanticscholar.org
A diet rich in fruits and vegetables has been identified to confer multiple health benefits,
including the reduction of cardiovascular disease risk. Fruits like apple, grape berry, olive …