Therapies targeting late events in Alzheimer's disease (AD), including aggregation of
amyloid beta (Aβ) and hyperphosphorylated tau, have largely failed, probably because they …

Abstract Brain arteriolosclerosis (B-ASC), characterized by pathologic arteriolar wall
thickening, is a common finding at autopsy in aged persons and is associated with cognitive …

Cerebrovascular disease (CVD) and Alzheimer's disease (AD) have more in common than
their association with ageing. They share risk factors and overlap neuropathologically. Most …

There are no generally accepted protocols for post-mortem assessment in cases of
suspected vascular cognitive impairment. Neuropathologists from seven UK centres have …

Background Alzheimer's disease (AD) is the most common form of dementia, characterized
by progressive cognitive impairment and neurodegeneration. However, despite extensive …

Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional
changes to the cerebral vasculature contribute to disease pathology and cognitive decline in …

Mid-life hypertension and cerebrovascular dysfunction are associated with increased risk of
later life dementia, including Alzheimer's disease (AD). The classical renin–angiotensin …

While the accumulation and aggregation of amyloid-β and tau are central events in the
pathogenesis of Alzheimer's disease, there is increasing evidence that cerebrovascular …

Alzheimer's disease (AD) has become a severe medical challenge. Advances in
technologies produced high-dimensional data of different modalities including functional …

Recent studies implicate loss of pericytes in hypoperfusion and blood–brain barrier (BBB)
leakage in Alzheimer's disease (AD). In this study, we have measured levels of the pericyte …