Chronic graft-versus-host disease (GVHD) remains a vexing and dangerous complication of
allogeneic stem cell transplantation. Mild forms of chronic GVHD are often manageable with …

In less than 10 years, the prognosis of chronic myeloid leukaemia has changed from that of
a fatal disease to a disorder amenable simply to lifelong oral medication and compatible …

Background aims Natural killer (NK) cells, either naive or genetically engineered, are
increasingly considered for cellular therapy of patients with malignancies. When using NK …

Over the last 60 years, more than a million patients received hematopoietic cell
transplantation. Having incorporated multiple changes in clinical practices, it remains a …

The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the
engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia …

Background Since allogeneic stem-cell transplantation can induce curative graft-versus-
leukemia reactions in patients with hematologic cancers, we sought to induce analogous …

The graft-versus-tumour effect seen after allogeneic (genetically different) haematopoietic
cell transplantation for human malignancies represents the clearest example of the power of …

Donor lymphocyte infusion (DLI) into patients with a relapse of their leukemia or multiple
myeloma after allogeneic stem cell transplantation (alloSCT) has been shown to be a …

PURPOSE: To determine the efficacy, toxicity, and long-term outcome and prognostic factors
of donor lymphocyte infusions (DLI) in patients with relapsed multiple myeloma (MM) after …

Adoptive immunotherapy with allogeneic purified natural killer (NK) cell products might exert
graft-versus-tumor alloreactivity with little risk of GVHD. In a prospective phase II study in two …