[HTML][HTML] Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments

Z Yuan, Y Li, S Zhang, X Wang, H Dou, X Yu, Z Zhang… - Molecular cancer, 2023 - Springer
The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

One-dimensional nanomaterials for cancer therapy and diagnosis

J Shin, N Kang, B Kim, H Hong, L Yu, J Kim… - Chemical Society …, 2023 - pubs.rsc.org
One-dimensional (1-D) nanomaterials possess unique shape-dependent phyicochemical
properties and are increasingly recognized as promising materials for nanotechnology. 1-D …

Mechanical stimuli-driven cancer therapeutics

J An, H Hong, M Won, H Rha, Q Ding, N Kang… - Chemical Society …, 2023 - pubs.rsc.org
Mechanical stimulation utilizing deep tissue-penetrating and focusable energy sources,
such as ultrasound and magnetic fields, is regarded as an emerging patient-friendly and …

Static and dynamic: evolving biomaterial mechanical properties to control cellular mechanotransduction

W Xie, X Wei, H Kang, H Jiang, Z Chu, Y Lin… - Advanced …, 2023 - Wiley Online Library
The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical,
biological, and chemical signals to embraced cells. Increasing evidence suggests that …

[HTML][HTML] Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging

MJ Ko, S Min, H Hong, W Yoo, J Joo, YS Zhang… - Bioactive Materials, 2024 - Elsevier
Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to
conventional cancer treatment regimens. Its effective use as a cancer therapy requires a …

Harnessing the therapeutic potential of extracellular vesicles for biomedical applications using multifunctional magnetic nanomaterials

L Yang, KD Patel, C Rathnam, R Thangam, Y Hou… - Small, 2022 - Wiley Online Library
Extracellular vesicles (eg, exosomes) carrying various biomolecules (eg, proteins, lipids,
and nucleic acids) have rapidly emerged as promising platforms for many biomedical …

Advanced materials and sensors for microphysiological systems: focus on electronic and electrooptical interfaces

H Kavand, R Nasiri, A Herland - Advanced Materials, 2022 - Wiley Online Library
Advanced in vitro cell culture systems or microphysiological systems (MPSs), including
microfluidic organ‐on‐a‐chip (OoC), are breakthrough technologies in biomedicine. These …

Manipulating nanoparticle aggregates regulates receptor–ligand binding in macrophages

Y Kim, HJ Jung, Y Lee, S Koo, R Thangam… - Journal of the …, 2022 - ACS Publications
The receptor–ligand interactions in cells are dynamically regulated by modulation of the
ligand accessibility. In this study, we utilize size-tunable magnetic nanoparticle aggregates …

Photoswitchable Microgels for dynamic macrophage modulation

Y Kim, R Thangam, J Yoo, J Heo, JY Park… - Advanced …, 2022 - Wiley Online Library
Dynamic manipulation of supramolecular self‐assembled structures is achieved irreversibly
or under non‐physiological conditions, thereby limiting their biomedical, environmental, and …

Modulation of macrophages by in situ ligand bridging

SY Kim, R Thangam, N Kang, H Hong… - Advanced Functional …, 2023 - Wiley Online Library
Extracellular matrix (ECM) proteins containing cell‐attachable Arg‐Gly‐Asp (RGD)
sequences exhibit variable bridging and non‐bridging in fibronectin‐collagen and laminin …