Advances in genomics technology have provided the means to probe myriad chromatin
interactions at unprecedented spatial and temporal resolution. This has led to a profound …

Promoters are crucial for gene regulation. They vary greatly in terms of associated regulatory
elements, sequence motifs, the choice of transcription start sites and other features. Several …

Regulated transcription controls the diversity, developmental pathways and spatial
organization of the hundreds of cell types that make up a mammal. Using single-molecule …

Centromeres are the specialized regions of the chromosomes that direct faithful
chromosome segregation during cell division. Despite their functional conservation …

A core promoter is a stretch of DNA surrounding the transcription start site (TSS) that
integrates regulatory inputs and recruits general transcription factors to initiate transcription …

Epigenetic information is available from contemporary organisms, but is difficult to track back
in evolutionary time. Here, we show that genome-wide epigenetic information can be …

Centromeres mediate the pairing of homologous chromosomes during meiosis; this pairing
is particularly challenging for polyploid plants such as hexaploid bread wheat (Triticum …

There has been a recent surge in the use of genome-wide methodologies to identify and
annotate the transcriptional regulatory elements in the human genome. Here we review …

Nucleosome positioning is an important process required for proper genome packing and its
accessibility to execute the genetic program in a cell-specific, timely manner. In the recent …

Plant and animal centromeres comprise megabases of highly repeated satellite sequences,
yet centromere function can be specified epigenetically on single-copy DNA by the presence …