Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects
R Kandasamy, TM Hillhouse… - Proceedings of the …, 2021 - National Acad Sciences
Positive allosteric modulators (PAMs) of the mu-opioid receptor (MOR) have been
hypothesized as potentially safer analgesics than traditional opioid drugs. This is based on …
hypothesized as potentially safer analgesics than traditional opioid drugs. This is based on …
[HTML][HTML] Exosomes released by granulocytic myeloid-derived suppressor cells attenuate DSS-induced colitis in mice
Myeloid-derived suppressor cells (MDSC) have been described in inflammatory bowel
disease (IBD), but their role in the disease remains controversial. We sought to define the …
disease (IBD), but their role in the disease remains controversial. We sought to define the …
Molecular insight into the anti-inflammatory effects of the curcumin ester prodrug curcumin diglutaric acid in vitro and in vivo
R Phumsuay, C Muangnoi, PW Dasuni Wasana… - International Journal of …, 2020 - mdpi.com
Curcumin diglutaric acid (CurDG), an ester prodrug of curcumin, has the potential to be
developed as an anti-inflammatory agent due to its improved solubility and stability. In this …
developed as an anti-inflammatory agent due to its improved solubility and stability. In this …
Characterization of the structural, optical, photocatalytic and in vitro and in vivo anti-inflammatory properties of Mn 2+ doped Zn 2 GeO 4 nanorods
VY Suzuki, LHC Amorin, NM Lima… - Journal of Materials …, 2019 - pubs.rsc.org
The effect of Mn incorporation on the structural, optical, and photocatalytic properties of
Zn2GeO4 (ZGO) host matrices was investigated. Moreover, the ability to modulate in vitro …
Zn2GeO4 (ZGO) host matrices was investigated. Moreover, the ability to modulate in vitro …
Citronellol, a natural acyclic monoterpene, attenuates mechanical hyperalgesia response in mice: Evidence of the spinal cord lamina I inhibition
RG Brito, PL Dos Santos, JSS Quintans… - Chemico-Biological …, 2015 - Elsevier
We evaluated the anti-hyperalgesic effect of citronellol (CT) and investigated the spinal cord
lamina I involvement in this effect. Male mice were pre-treated with CT (25, 50 and 100 …
lamina I involvement in this effect. Male mice were pre-treated with CT (25, 50 and 100 …
A new lipophilic amino alcohol, chemically similar to compound FTY720, attenuates the pathogenesis of experimental autoimmune encephalomyelitis by PI3K/Akt …
LC da Silva, IV de Assis Lima, MCM da Silva… - International …, 2020 - Elsevier
Experimental autoimmune encephalomyelitis (EAE) is one of the main animal models used
for the study of Multiple Sclerosis (MS). Long-chain lipophilic amino alcohols with …
for the study of Multiple Sclerosis (MS). Long-chain lipophilic amino alcohols with …
Identification of WP1066, an inhibitor of JAK2 and STAT3, as a KV1.3 potassium channel blocker
M Li, H Yu - British Journal of Pharmacology, 2021 - Wiley Online Library
Background and Purpose KV1. 3 potassium channels play a predominant role in regulating
calcium signalling that is essential for the activation and proliferation of effector memory T …
calcium signalling that is essential for the activation and proliferation of effector memory T …
In vitro and in vivo evaluation of anti-inflammatory activity and free radical scavenging potential of leaves extract from Anadenanthera colubrina
OC Junior, NM Lima, MGA Silva, VB Aguiar… - Natural Product …, 2021 - Taylor & Francis
The present study highlights the antioxidant and anti-inflammatory activities from
Anadenanthera colubrina leaves ethanolic extract (EEAc) and its phytochemical profile. The …
Anadenanthera colubrina leaves ethanolic extract (EEAc) and its phytochemical profile. The …
In vitro and in vivo evaluation of 2-aminoalkanol and 1,2-alkanediamine derivatives against Strongyloides venezuelensis
AL Legarda-Ceballos, J López-Abán, E Del Olmo… - Parasites & …, 2016 - Springer
Background Strongyloidiasis is a parasitic disease widely present in tropical and subtropical
areas. Strongyloides stercoralis represents the main species that infects human beings …
areas. Strongyloides stercoralis represents the main species that infects human beings …
Abrogation of Acute Inflammation in ICR Mice with Topical Administration of Philippine Stingless Bee (Tetragonula biroi Friese) Honey
MJM Desamero, MBA Rabino, MAR Tayao… - Pharmacognosy …, 2023 - phcogres.com
Background: Honey, a sweet sugar-rich bee-derived product, has been widely recognized in
the realm of Ayurveda and Pharmacognosy for the treatment of various inflammatory …
the realm of Ayurveda and Pharmacognosy for the treatment of various inflammatory …