The effects of exercise and activity-based physical therapy on bone after spinal cord injury
Spinal cord injury (SCI) produces paralysis and a unique form of neurogenic disuse
osteoporosis that dramatically increases fracture risk at the distal femur and proximal tibia …
osteoporosis that dramatically increases fracture risk at the distal femur and proximal tibia …
Rehabilitation: neurogenic bone loss after spinal cord injury
GE Leone, DC Shields, A Haque, NL Banik - Biomedicines, 2023 - mdpi.com
Osteoporosis is a common skeletal disorder which can severely limit one's ability to
complete daily tasks due to the increased risk of bone fractures, reducing quality of life …
complete daily tasks due to the increased risk of bone fractures, reducing quality of life …
[HTML][HTML] Poly (ADP-ribose) polymerase family member 14 promotes functional recovery after spinal cord injury through regulating microglia M1/M2 polarization via …
AH Xu, Y Yang, Y Shao, MY Jiang… - Neural Regeneration …, 2023 - journals.lww.com
Poly (ADP-ribose) polymerase family member 14 (PARP14), which is an intracellular mono
(ADP-ribosyl) transferase, has been reported to promote post-stroke functional recovery, but …
(ADP-ribosyl) transferase, has been reported to promote post-stroke functional recovery, but …
Chronic intermittent hypobaric hypoxia ameliorates osteoporosis after spinal cord injury through balancing osteoblast and osteoclast activities in rats
L Zhang, Y Yin, J Guo, L Jin, Z Hou - Frontiers in Endocrinology, 2023 - frontiersin.org
Introduction As a common complication of spinal cord injury (SCI), most SCI patients suffer
from osteoporosis. In our previous study, chronic intermittent hypobaric hypoxia (CIHH) …
from osteoporosis. In our previous study, chronic intermittent hypobaric hypoxia (CIHH) …
Electrical stimulation of hindlimb skeletal muscle has beneficial effects on sublesional bone in a rat model of spinal cord injury
Spinal cord injury (SCI) results in marked atrophy of sublesional skeletal muscle and
substantial loss of bone. In this study, the effects of prolonged electrical stimulation (ES) …
substantial loss of bone. In this study, the effects of prolonged electrical stimulation (ES) …
[HTML][HTML] Sciatic neurectomy-related cortical bone loss exhibits delayed onset yet stabilises more rapidly than trabecular bone
Disuse osteoporosis occurs after extended periods of bed rest or nerve damage leading to
increased risk of fracture. It remains to be established, however, whether the trajectory of …
increased risk of fracture. It remains to be established, however, whether the trajectory of …
Locomotor training with adjuvant testosterone preserves cancellous bone and promotes muscle plasticity in male rats after severe spinal cord injury
Loading and testosterone may influence musculoskeletal recovery after spinal cord injury
(SCI). Our objectives were to determine (a) the acute effects of bodyweight‐supported …
(SCI). Our objectives were to determine (a) the acute effects of bodyweight‐supported …
Bone loss after severe spinal cord injury coincides with reduced bone formation and precedes bone blood flow deficits
JF Yarrow, RD Wnek, CF Conover… - Journal of Applied …, 2021 - journals.physiology.org
Diminished bone perfusion develops in response to disuse and has been proposed as a
mechanism underlying bone loss. Bone blood flow (BF) has not been investigated within the …
mechanism underlying bone loss. Bone blood flow (BF) has not been investigated within the …
Administration of high-dose methylprednisolone worsens bone loss after acute spinal cord injury in rats
The administration of high-dose methylprednisolone (MP) for 24–48 h after traumatic spinal
cord injury (SCI) has been shown to improve functional recovery. The known adverse effects …
cord injury (SCI) has been shown to improve functional recovery. The known adverse effects …
Transcriptomics reveals transient and dynamic muscle fibrosis and atrophy differences following spinal cord injury in rats
HJ Kok, DB Fletcher, JC Oster… - Journal of Cachexia …, 2024 - Wiley Online Library
Background The rate and magnitude of skeletal muscle wasting after severe spinal cord
injury (SCI) exceeds most other disuse conditions. Assessing the time course of molecular …
injury (SCI) exceeds most other disuse conditions. Assessing the time course of molecular …