Review of synthesis of 1, 3, 4-oxadiazole derivatives

KD Patel, SM Prajapati, SN Panchal… - Synthetic …, 2014 - Taylor & Francis
Oxadiazole nucleus shows a broad spectrum of pharmaceutical applications. Thus, in recent
years scientists have developed various new methods for the synthesis of its derivatives …

Synthesis and antifungal activities of 5-(3, 4, 5-trimethoxyphenyl)-2-sulfonyl-1, 3, 4-thiadiazole and 5-(3, 4, 5-trimethoxyphenyl)-2-sulfonyl-1, 3, 4-oxadiazole …

CJ Chen, BA Song, S Yang, GF Xu, PS Bhadury… - Bioorganic & medicinal …, 2007 - Elsevier
Starting from the key intermediate 5-(3, 4, 5-trimethoxyphenyl)-1, 3, 4-thiadiazole-2-thiol (4)
or the oxadiazole analogue (5), the title compounds 9 and 10 are synthesized by a two-step …

Synthesis, structure, and bioactivity of N′-substituted benzylidene-3, 4, 5-trimethoxybenzohydrazide and 3-acetyl-2-substituted phenyl-5-(3, 4, 5-trimethoxyphenyl)-2 …

L Jin, J Chen, B Song, Z Chen, S Yang, Q Li… - Bioorganic & medicinal …, 2006 - Elsevier
Some 3-acetyl-2-substituted phenyl-5-(3, 4, 5-trimethoxyphenyl)-2, 3-dihydro-1, 3, 4-
oxadiazole derivatives were synthesized by cyclization reaction of N′-substituted …

[HTML][HTML] Biochemical evaluation of a series of synthetic chalcone and hydrazide derivatives as novel inhibitors of cruzain from Trypanosoma cruzi

DM Borchhardt, A Mascarello, LD Chiaradia… - Journal of the Brazilian …, 2010 - SciELO Brasil
Chagas' disease, a parasitic infection widely distributed throughout Latin America, is a major
public health problem with devastating consequences in terms of human morbidity and …

Electrocyclization of semicarbazone; A novel route of green synthesis of 2, 5-disubstituted-1, 3, 4-oxadiazoles

B Lotfi, B Mustafa, B Leila, M Salima - International Journal of …, 2011 - Elsevier
The anodic oxidation of a number of arylsemicarbazides derivatives (I) has been examined
in acetonitril containing lithium perchlorate (LiClO4) as a supporting electrolyte (20g/l). The …

[PDF][PDF] Synthesis and biological screening of some new substituted-3H-quinazolin-4-one analogs as antimicrobial agents

MA Al-Omar, SG Abdel Hamide… - Saudi pharmaceutical …, 2005 - academia.edu
A new series of substituted 3-benzyl-3H-quinazolin-4-one analogs was prepared and
screened for their antimicrobial activity. Compound 2-(3-nitro-2-pyridyl) thio-3-benzyl-6 …

An expeditious and one-pot synthesis of unsymmetrical 2, 5-disubstituted-1, 3, 4-oxadiazoles under microwave irradiation and solvent-free conditions

N Montazeri, K Rad-Moghadam - Chinese Chemical Letters, 2008 - Elsevier
A one-pot synthesis of some unsymmetrical 2, 5-disubstituted-1, 3, 4-oxadiazoles via
cyclocondensation of benzoylhydrazines with orthoesters under solvent-free and microwave …

[PDF][PDF] Synthesis and biological screening of some new substituted 2-mercapto-4 (3H) quinazolinone analogues as anticonvulsant agents

AA Kadi, AS El-Azab, AM Alafeefy, SG Abdel-Hamide - J. Pharma. Sci, 2006 - Citeseer
Epilepsy is a very common disorder, characterized by seizures, which takes various form
and result from episodic neuronal discharges. Current antiepileptic drugs are effective in …

1, 3, 4-Oxadiazole formation; a novel solid support strategy

JP Kilburn, J Lau, RCF Jones - Tetrahedron Letters, 2001 - Elsevier
A new approach to the synthesis of 1, 3, 4-oxadiazoles on solid support is described. Resin
bound 1-acyl thiosemicarbazides were treated with a variety of dehydrating agents at …

(2-Arylhydrazonomethyl)-substituted xanthones as antimycotics: synthesis and fungistatic activity against Candida species

S Moreau, M Varache-Lembège, S Larrouture… - European journal of …, 2002 - Elsevier
A series of arylhydrazones derived from various 6, 8-diacetoxy-or 6, 8-dihydroxy-9-oxo-9H-
xanthene carboxaldehydes were synthesized and evaluated for their in vitro antifungal …