The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense
against cancer. Although some evidence shows that NK cells can develop in secondary …

Interferon-gamma (IFN-γ) is a pleiotropic molecule with associated antiproliferative, pro-
apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major …

Interferon-gamma (IFNG) augments immune function yet promotes T cell exhaustion through
PDL1. How these opposing effects are integrated to impact immune checkpoint blockade …

Tissue health is dictated by the capacity to respond to perturbations and then return to
homeostasis. Mechanisms that initiate, maintain, and regulate immune responses in tissues …

Interferon-gamma (IFNG) has long been implicated as a central orchestrator of antitumor
immune responses in the elimination stage of the immunoediting paradigm. However …

Metastasis accounts for 90% of cancer-related deaths and, currently, there are no effective
clinical therapies to block the metastatic cascade. A need to develop novel therapies …

Interferon-gamma (IFNG) is a pleiotropic cytokine that modulates both innate and adaptive
immune networks; it is the most potent activator of macrophages and a signature cytokine of …

Aspergillus fumigatus is an ubiquitous, saprophytic mould that forms and releases airborne
conidia which are inhaled by humans on a daily basis. When the immune system is …

Altered interactions between the gut mucosa and bacteria during HIV infection seem to
contribute to chronic immune dysfunction. A deeper understanding of how nutritional …