Advances in the study of brain development over the last decades, especially recent findings
regarding the evolutionary expansion of the human neocortex, and large-scale analyses of …

The bone morphogenetic proteins (BMPs) are a group of powerful morphogens that are
critical for development of the nervous system. The effects of BMP signaling on neural stem …

During adult hippocampal neurogenesis, most newborn cells undergo apoptosis and are
rapidly phagocytosed by resident microglia to prevent the spillover of intracellular contents …

Transcriptional regulation is a critical mechanism in the birth, specification, and
differentiation of granule neurons in the adult hippocampus. One of the first negative-acting …

Abstract mRNA expression profiling has suggested the existence of multiple glioblastoma
subclasses, but their number and characteristics vary among studies and the etiology …

Astrocytes have essential functions in brain homeostasis that are established late in
differentiation, but the mechanisms underlying the functional maturation of astrocytes are not …

Complementary transcriptional and epigenetic regulatory factors (eg, histone and chromatin
modifying enzymes and non-coding RNAs) regulate genes responsible for mediating neural …

Astrocytes emerge as crucial cells for proper neuronal functioning in the developing and
adult brain. Neurons and astrocytes are sequentially generated from the same pool of neural …

During neurogenesis, specific transcription factors are needed to repress neuronal genes in
nonneuronal cells to ensure precise development. Repressor element-1 binding …

Nerve cell development in the brain is a tightly regulated process. The generation of
neurons from precursor cells, their migration to the appropriate target sites, their extensive …