One of the most prevalent cancers impacting women worldwide is breast cancer. Although
there are several risk factors for breast cancer, the p53 gene's function has recently received …

P53 Phase separation is crucial towards amyloid aggregation and p63 and p73 have
enhanced expression in tumors. This study examines the phase behaviors of p53, p63, and …

Liquid–Liquid phase separation (LLPS) of p53 to form liquid condensates has been
implicated in cellular functions and dysfunctions. The p53 condensates may serve as …

The pre-tetramerization loop (PTL) of the human tumor suppressor protein p53 is an
intrinsically disordered region (IDR) necessary for the tetramerization process, and its …

Background Cancer as a deathly disease with high prevalence has impelled researchers to
investigate its causative mechanisms in the search for effective therapeutics. Recently, the …

Intrinsically disordered proteins (IDPs) defy the conventional structure–function paradigm
and do not autonomously fold up into unique 3D structures for carrying out functions. They …

Phase separation (PS) of p53 is critical in its path to amyloid aggregation, a process linked
to cancer. P63 and p73 exhibit dual roles as tumor suppressors and oncogenes and are …

Phase separation (PS) of p53 is critical in its path to amyloid aggregation, a process linked
to cancer. P63 and p73 exhibit dual roles as tumor suppressors and oncogenes and are …