[HTML][HTML] The lymphatic vasculature in the 21st century: novel functional roles in homeostasis and disease

G Oliver, J Kipnis, GJ Randolph, NL Harvey - Cell, 2020 - cell.com
Mammals have two specialized vascular circulatory systems: the blood vasculature and the
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …

Lymphatic malformations: genetics, mechanisms and therapeutic strategies

T Mäkinen, LM Boon, M Vikkula, K Alitalo - Circulation research, 2021 - Am Heart Assoc
Lymphatic vessels maintain tissue fluid homeostasis by returning to blood circulation
interstitial fluid that has extravasated from the blood capillaries. They provide a trafficking …

[HTML][HTML] Lymphatic vessel network structure and physiology

JW Breslin, Y Yang, JP Scallan, RS Sweat… - Comprehensive …, 2018 - ncbi.nlm.nih.gov
The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …

Vascular heterogeneity and specialization in development and disease

M Potente, T Mäkinen - Nature Reviews Molecular Cell Biology, 2017 - nature.com
Blood and lymphatic vessels pervade almost all body tissues and have numerous essential
roles in physiology and disease. The inner lining of these networks is formed by a single …

Vascular endothelial growth factor signaling in development and disease

S Karaman, VM Leppänen, K Alitalo - Development, 2018 - journals.biologists.com
Vascular endothelial growth factors (VEGFs) are best known for their involvement in
orchestrating the development and maintenance of the blood and lymphatic vascular …

[HTML][HTML] Whole-brain imaging with single-cell resolution using chemical cocktails and computational analysis

EA Susaki, K Tainaka, D Perrin, F Kishino, T Tawara… - Cell, 2014 - cell.com
Systems-level identification and analysis of cellular circuits in the brain will require the
development of whole-brain imaging with single-cell resolution. To this end, we performed …

Development and plasticity of meningeal lymphatic vessels

S Antila, S Karaman, H Nurmi, M Airavaara… - Journal of Experimental …, 2017 - rupress.org
The recent discovery of meningeal lymphatic vessels (LVs) has raised interest in their
possible involvement in neuropathological processes, yet little is known about their …

Cardiac lymphatics are heterogeneous in origin and respond to injury

L Klotz, S Norman, JM Vieira, M Masters, M Rohling… - Nature, 2015 - nature.com
The lymphatic vasculature is a blind-ended network crucial for tissue-fluid homeostasis,
immune surveillance and lipid absorption from the gut. Recent evidence has proposed an …

Lymphatic system in cardiovascular medicine

A Aspelund, MR Robciuc, S Karaman… - Circulation …, 2016 - Am Heart Assoc
The mammalian circulatory system comprises both the cardiovascular system and the
lymphatic system. In contrast to the blood vascular circulation, the lymphatic system forms a …

The role of fatty acid β-oxidation in lymphangiogenesis

BW Wong, X Wang, A Zecchin, B Thienpont… - Nature, 2017 - nature.com
Lymphatic vessels are lined by lymphatic endothelial cells (LECs), and are critical for health.
However, the role of metabolism in lymphatic development has not yet been elucidated …