The role of m6A RNA methylation in cancer metabolism

Y An, H Duan - Molecular cancer, 2022 - Springer
Metabolic reprogramming is one of the main characteristics of malignant tumors, which is
due to the flexible changes of cell metabolism that can meet the needs of cell growth and …

Historic obstacles and emerging opportunities in the field of developmental metabolism–lessons from Heidelberg

AM Garfinkel, E Ilker, H Miyazawa… - …, 2024 - journals.biologists.com
The field of developmental metabolism is experiencing a technological revolution that is
opening entirely new fields of inquiry. Advances in metabolomics, small-molecule sensors …

Membrane potential regulates Hedgehog signalling in the Drosophila wing imaginal disc

M Emmons‐Bell, IK Hariharan - EMBO reports, 2021 - embopress.org
While the membrane potential of cells has been shown to be patterned in some tissues,
specific roles for membrane potential in regulating signalling pathways that function during …

The role of RNA methylation in tumor immunity and its potential in immunotherapy

Y Li, H Jin, Q Li, L Shi, Y Mao, L Zhao - Molecular Cancer, 2024 - Springer
RNA methylation, a prevalent post-transcriptional modification, has garnered considerable
attention in research circles. It exerts regulatory control over diverse biological functions by …

Metabolomic analysis of Drosophila melanogaster larvae lacking pyruvate kinase

Y Heidarian, JP Tourigny, TD Fasteen… - G3: Genes …, 2024 - academic.oup.com
Pyruvate kinase (Pyk) is a rate-limiting enzyme that catalyzes the final metabolic reaction in
glycolysis. The importance of this enzyme, however, extends far beyond ATP production, as …

Cultivation and Live Imaging of Drosophila Imaginal Discs

NA Dye - Drosophila: Methods and Protocols, 2022 - Springer
In this chapter, I present a method for the ex vivo cultivation and live imaging of Drosophila
imaginal disc explants using low concentrations of the steroid hormone 20 …

Hedgehog signaling can enhance glycolytic ATP production in the Drosophila wing disc

I Nellas, KV Iyer, JM Iglesias‐Artola, M Pippel… - EMBO …, 2022 - embopress.org
Adenosine triphosphate (ATP) production and utilization is critically important for animal
development. How these processes are regulated in space and time during tissue growth …

Hedgehog on track: Long-distant signal transport and transfer through direct cell-to-cell contact

AC Gradilla, I Guerrero - Current Topics in Developmental Biology, 2022 - Elsevier
Abstract The function of Hedgehog (Hh) as a morphogen results from its long-distance
distribution from producing to neighboring receiving cells within the developing tissue. This …

Optical estimation of absolute membrane potential using one-and two-photon fluorescence lifetime imaging microscopy

JR Lazzari-Dean, EW Miller - Bioelectricity, 2021 - liebertpub.com
Background: Membrane potential (V mem) exerts physiological influence across a wide
range of time and space scales. To study V mem in these diverse contexts, it is essential to …

[HTML][HTML] Growth across scales: Dynamic signaling impacts tissue size and shape

R Mateus, JF Fuhrmann, NA Dye - Current opinion in cell biology, 2021 - Elsevier
Organ and tissue growth result from an integration of biophysical communication across
biological scales, both in time and space. In this review, we highlight new insight into the …