Abstract The Pathosystems Resource Integration Center (PATRIC) is the all-bacterial
Bioinformatics Resource Center (BRC)(http://www. patricbrc. org). A joint effort by two of the …

Methylation and demethylation of DNA, RNA and proteins has emerged as a major
regulatory mechanism. Studying the function of these modifications would benefit from tools …

Drug discovery programs sponsored by public or private initiatives pursue the same
ambitious goal: a crushing defeat of major Neglected Tropical Diseases (NTDs) during this …

Infections with the pathogenic free-living amoebae Naegleria fowleri can lead to life-
threatening illnesses including catastrophic primary amoebic meningoencephalitis (PAM) …

High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb)
proteins provide templates for TB drug design, but are available for only a small fraction of …

Drugs targeting multiple stages of the Plasmodium vivax life cycle are needed to reduce the
health and economic burdens caused by malaria worldwide. N-myristoyltransferase (NMT) …

Highlights•New beta-lactamase inhibitor with novel mechanism of action is
reviewed.•Methods of targeting bacterial gyrase compounds are discussed.•Structures of …

Each year, approximately 50,000 children under 5 die as a result of diarrhea caused by
Cryptosporidium parvum, a protozoan parasite. There are currently no effective drugs or …

Quantitative and accurate detection of multiple biomarkers would allow for the rapid
diagnosis and treatment of diseases induced by pathogens. Monoclonal antibodies are …

Ion mobility (IM) is a gas-phase separation technique that is used to determine the collision
cross sections of native-like ions of proteins and protein complexes, which are in turn used …