GHB pharmacology and toxicology: acute intoxication, concentrations in blood and urine in forensic cases and treatment of the withdrawal syndrome

F P. Busardo, A W. Jones - Current neuropharmacology, 2015 - benthamdirect.com
The illicit recreational drug of abuse, γ-hydroxybutyrate (GHB) is a potent central nervous
system depressant and is often encountered during forensic investigations of living and …

The clinical toxicology of gamma-hydroxybutyrate, gamma-butyrolactone and 1, 4-butanediol

LJ Schep, K Knudsen, RJ Slaughter, JA Vale… - Clinical …, 2012 - Taylor & Francis
Introduction. Gamma-hydroxybutyrate (GHB) and its precursors, gamma-butyrolactone
(GBL) and 1, 4-butanediol (1, 4-BD), are drugs of abuse which act primarily as central …

Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse γ-hydroxybutyric acid

ME Morris, MA Felmlee - The AAPS journal, 2008 - Springer
The transport of monocarboxylates, such as lactate and pyruvate, is mediated by the
SLC16A family of proton-linked membrane transport proteins known as monocarboxylate …

Gamma hydroxybutyric acid (GHB) intoxication

PE Mason, WP Kerns - Academic Emergency Medicine, 2002 - Wiley Online Library
Gamma hydroxybutyric acid (GHB) is a naturally occurring analog of gamma‐aminobutyric
acid (GABA) that has been used in research and clinical medicine for many years. In the …

Gamma hydroxybutyrate (GHB), gamma butyrolactone (GBL) and 1, 4-butanediol (1, 4-BD; BDO): a literature review with a focus on UK fatalities related to non …

JM Corkery, B Loi, H Claridge, C Goodair… - Neuroscience & …, 2015 - Elsevier
Misuse of gamma hydroxybutrate (GHB) and gamma butyrolactone (GBL) has increased
greatly since the early 1990s, being implicated in a rising number of deaths. This paper …

Gamma hydroxy butyrate abuse and dependency

A Gonzalez, DJ Nutt - Journal of Psychopharmacology, 2005 - journals.sagepub.com
The recreational use of gamma hydroxy butyrate (GHB) has gained popularity over the last
decade. GHB was initially sold as a safe bodybuilding and fat burning compound. It is now …

An overview of gamma‐hydroxybutyric acid: pharmacodynamics, pharmacokinetics, toxic effects, addiction, analytical methods, and interpretation of results

H Andresen, BE Aydin, A Mueller… - Drug testing and …, 2011 - Wiley Online Library
Abuse of gamma‐hydroxybutyric acid (GHB) has been known since the early 1990's, but is
not as widespread as the consumption of other illegal drugs. However, the number of severe …

Gamma‐hydroxybutyrate–a drug of abuse

KR Drasbek, J Christensen… - Acta neurologica …, 2006 - Wiley Online Library
γ‐Hydroxybutyrate (GHB) is a drug of abuse that causes euphoria, anxiolysis, and hypnosis.
The recent rise in the recreational intake of GHB, as well as its association with 'drug rape' …

Pharmacokinetic properties of γ-hydroxybutyrate (GHB) in whole blood, serum, and urine

AD Brailsford, DA Cowan… - Journal of Analytical …, 2012 - academic.oup.com
Abstract Over the last 10–15 years, γ-hydroxybutyrate (GHB) and γ-butyrolactone have
become increasingly popular “club drugs”, but they have also gained attention as potential …

γ-Hydroxybutyric acid: neurobiology and toxicology of a recreational drug

CGT Wong, KFY Chan, KM Gibson, OC Snead - Toxicological reviews, 2004 - Springer
Abstract γ-Hydroxybutyric acid (GHB) is a short-chain fatty acid that occurs naturally in
mammalian brain where it is derived metabolically from γ-aminobutyric acid (GABA), the …