The complex mTORC2 is accepted to be the kinase that controls the phosphorylation of the
hydrophobic motif, a key regulatory switch for AGC kinases, although whether mTOR directly …

Scaffolding proteins organize the information flow from activated G protein-coupled
receptors (GPCRs) to intracellular effector cascades both spatially and temporally. By this …

Oncogenic BRAF mutations initiate tumor formation by unleashing the autoinhibited kinase
conformation and promoting RAS-decoupled proliferative RAF-MEK-ERK signaling. We …

cAMP-dependent protein kinase (PKAc) is a pivotal signaling protein in eukaryotic cells.
PKAc has two well-characterized regulatory subunit proteins, RI and RII (each having α and …

Most disease-related mutations that impair cAMP protein kinase A (PKA) signaling are
present within the regulatory (R) PKA RI alpha-subunit (RIα). Although mutations in the …

Cells continuously communicate changes in their microenvironment, both locally and
globally, with other cells in the organism. Integration of information arising from signaling …

Kinase-targeted therapies have the potential to improve the survival of patients with cancer.
However, the cancer-specific spectrum of kinase alterations exhibits distinct functional …

Abstract Over 30,000 protein-protein interactions with pathological implications have been
identified; yet, discovering and investigating drugs that target these specific interactions is …

Mutations at different stages of the mitogen-activated protein kinase (MAPK) signaling
pathway lead to aberrant activation of the involved protein kinase entities. These oncogenic …

The second messenger molecule cAMP links extracellular signals to intracellular responses.
The main cellular cAMP effector is the compartmentalized protein kinase A (PKA). Upon …