The emerging complexity of gene fusions in cancer
F Mertens, B Johansson, T Fioretos… - Nature Reviews Cancer, 2015 - nature.com
Structural chromosome rearrangements may result in the exchange of coding or regulatory
DNA sequences between genes. Many such gene fusions are strong driver mutations in …
DNA sequences between genes. Many such gene fusions are strong driver mutations in …
International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data
The classification of myeloid neoplasms and acute leukemias was last updated in 2016
within a collaboration between the World Health Organization (WHO), the Society for …
within a collaboration between the World Health Organization (WHO), the Society for …
Hematologic cancer after gene therapy for cerebral adrenoleukodystrophy
CN Duncan, JR Bledsoe, B Grzywacz… - … England Journal of …, 2024 - Mass Medical Soc
Background Gene therapy with elivaldogene autotemcel (eli-cel) consisting of autologous
CD34+ cells transduced with lentiviral vector containing ABCD1 complementary DNA (Lenti …
CD34+ cells transduced with lentiviral vector containing ABCD1 complementary DNA (Lenti …
Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN
The 2010 and 2017 editions of the European LeukemiaNet (ELN) recommendations for
diagnosis and management of acute myeloid leukemia (AML) in adults are widely …
diagnosis and management of acute myeloid leukemia (AML) in adults are widely …
Multifaceted role of PRDM proteins in human cancer
The PR/SET domain family (PRDM) comprise a family of genes whose protein products
share a conserved N-terminal PR [PRDI-BF1 (positive regulatory domain I-binding factor 1) …
share a conserved N-terminal PR [PRDI-BF1 (positive regulatory domain I-binding factor 1) …
A distinct human cell type expressing MHCII and RORγt with dual characteristics of dendritic cells and type 3 innate lymphoid cells
A Ulezko Antonova, S Lonardi… - Proceedings of the …, 2023 - National Acad Sciences
Recent studies have characterized various mouse antigen-presenting cells (APCs)
expressing the lymphoid-lineage transcription factor RORγt (Retinoid-related orphan …
expressing the lymphoid-lineage transcription factor RORγt (Retinoid-related orphan …
ETV6 mutations in early immature human T cell leukemias
P Van Vlierberghe, A Ambesi-Impiombato… - Journal of Experimental …, 2011 - rupress.org
Early immature T cell acute lymphoblastic leukemias (T-ALLs) account for∼ 5–10% of
pediatric T-ALLs and are associated with poor prognosis. However, the genetic defects that …
pediatric T-ALLs and are associated with poor prognosis. However, the genetic defects that …
A network of epigenetic regulators guides developmental haematopoiesis in vivo
HT Huang, KL Kathrein, A Barton, Z Gitlin… - Nature cell …, 2013 - nature.com
The initiation of cellular programs is orchestrated by key transcription factors and chromatin
regulators that activate or inhibit target gene expression. To generate a compendium of …
regulators that activate or inhibit target gene expression. To generate a compendium of …
The multifaceted roles of PRDM16: adipose biology and beyond
J Chi, P Cohen - Trends in Endocrinology & Metabolism, 2016 - cell.com
The PRDM [PRDI-BFI (positive regulatory domain I-binding factor 1) and RIZ1
(retinoblastoma protein-interacting zinc finger gene 1) homologous domain containing] …
(retinoblastoma protein-interacting zinc finger gene 1) homologous domain containing] …
Pancreatic cancer patient survival correlates with DNA methylation of pancreas development genes
MJ Thompson, L Rubbi, DW Dawson, TR Donahue… - PloS one, 2015 - journals.plos.org
DNA methylation is an epigenetic mark associated with regulation of transcription and
genome structure. These markers have been investigated in a variety of cancer settings for …
genome structure. These markers have been investigated in a variety of cancer settings for …