Neutrophils are frontline cells of the innate immune system. These effector leukocytes are
equipped with intriguing antimicrobial machinery and consequently display high cytotoxic …

The global obesity epidemic is a major contributor to chronic disease and disability in the
world today. Since the discovery of leptin in 1994, a multitude of studies have characterized …

Non-small cell lung cancer (NSCLC) is characterized by molecular heterogeneity with
diverse immune cell infiltration patterns, which has been linked to therapy sensitivity and …

Chemokines are recognized as the most critical mediators for selective neutrophil
recruitment during inflammatory conditions. Furthermore, they are considered fundamental …

Dendritic cells (DCs) are professional antigen-presenting cells responsible for the activation
of specific T-cell responses and for the development of immune tolerance. Immature DCs …

Among heterogeneous primary tumors of the central nervous system (CNS), gliomas are the
most frequent type, with glioblastoma multiforme (GBM) characterized with the worst …

Despite increasing recognition of the importance of GM-CSF in autoimmune disease, it
remains unclear how GM-CSF is regulated at sites of tissue inflammation. Using GM-CSF …

Multisystem inflammatory syndrome in children (MIS-C) is a delayed-onset, COVID-19-
related hyperinflammatory illness characterized by severe acute respiratory syndrome …

CCRL2 is a seven-transmembrane domain receptor that belongs to the chemokine receptor
family. At difference from other members of this family, CCRL2 does not promote chemotaxis …

Macrophages are the key regulator of T-cell responses depending on their activation state.
CC motif chemokine receptor-like 2 (CCRL2), a nonsignaling atypical receptor originally …