Toll-like receptors: regulators of the immune response in the human gut

H Hug, MH Mohajeri, G La Fata - Nutrients, 2018 - mdpi.com
Toll-like receptors (TLRs) are powerful molecular regulators by which the immune system
may “sense” the environment and protect the host from pathogens or endogenous threats. In …

Vaccine technologies: From whole organisms to rationally designed protein assemblies

CP Karch, P Burkhard - Biochemical pharmacology, 2016 - Elsevier
Vaccines have been the single most significant advancement in public health, preventing
morbidity and mortality in millions of people annually. Vaccine development has traditionally …

Fighting Antibiotic‐Resistant Bacteria: Promising Strategies Orchestrated by Molecularly Imprinted Polymers

B Tse Sum Bui, T Auroy, K Haupt - … Chemie International Edition, 2022 - Wiley Online Library
Infections caused by antibiotic‐resistant bacteria are difficult and sometimes impossible to
treat, making them one of the major public health problems of our time. We highlight how …

Immunoinformatics-aided design of a peptide based multiepitope vaccine targeting glycoproteins and membrane proteins against monkeypox virus

N Akhtar, V Kaushik, RK Grewal, AK Wani… - Viruses, 2022 - mdpi.com
Monkeypox is a self-limiting zoonotic viral disease and causes smallpox-like symptoms. The
disease has a case fatality ratio of 3–6% and, recently, a multi-country outbreak of the …

Bacterial flagellar filament: a supramolecular multifunctional nanostructure

M Nedeljković, DE Sastre, EJ Sundberg - International Journal of …, 2021 - mdpi.com
The bacterial flagellum is a complex and dynamic nanomachine that propels bacteria
through liquids. It consists of a basal body, a hook, and a long filament. The flagellar filament …

Potential adjuvants for the development of a SARS-CoV-2 vaccine based on experimental results from similar coronaviruses

T Gupta, SK Gupta - International immunopharmacology, 2020 - Elsevier
The extensive efforts around the globe are being made to develop a suitable vaccine
against COVID-19 (Coronavirus Disease-19) caused by SARS-CoV-2 (Severe Acute …

In-silico design of a multivalent epitope-based vaccine against Candida auris

N Akhtar, A Joshi, V Kaushik, M Kumar… - Microbial …, 2021 - Elsevier
Candida auris is a rapidly emerging human pathogenic fungus with a high mortality rate.
Recent report suggests that the new clinical isolates are showing resistance to the major …

Immunoinformatics designed T cell multi epitope dengue peptide vaccine derived from non structural proteome

S Krishnan, A Joshi, N Akhtar, V Kaushik - Microbial Pathogenesis, 2021 - Elsevier
Dengue viral disease has been reported as an Aedes aegypti mosquito-borne human
disease and causing a severe global public health concern. In this study, immunoinformatics …

Design of a multi-epitope vaccine against the pathogenic fungi Candida tropicalis using an in silico approach

N Akhtar, A Singh, AK Upadhyay… - Journal of Genetic …, 2022 - Elsevier
Background Candida tropicalis causes tropical invasive fungal infections, with a high
mortality. This fungus has been found to be resistant to antifungal classes such as azoles …

Design of a novel and potent multivalent epitope based human cytomegalovirus peptide vaccine: an immunoinformatics approach

N Akhtar, A Joshi, J Singh, V Kaushik - Journal of Molecular Liquids, 2021 - Elsevier
Human Cytomegalovirus (HCMV) is one of the most common causes of congenital infections
globally. They infect the fetus and cause severe birth defects such as hearing loss …