Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Obesity is the most common cause of insulin resistance, and the current obesity epidemic is
driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic …

The pandemic of coronavirus disease 2019 (COVID-19) and its pathogen, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the greatest current threat …

Significance: Antioxidant and redox signaling (ARS) events are regulated by critical
molecules that modulate antioxidants, reactive oxygen species (ROS) or reactive nitrogen …

Abstract Hypoxia-inducible factors (HIFs), a family of transcription factors activated by
hypoxia, consist of three α-subunits (HIF1α, HIF2α and HIF3α) and one β-subunit (HIF1β) …

Elucidating the mechanisms by which short chain fatty acids (SCFA) reduce body weight
may assist in the development of an effective weight control strategy. Dietary …

Adipose tissue regulates numerous physiological processes, and its dysfunction in obese
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …

Oxygen is essentially required by most eukaryotic organisms as a scavenger to remove
harmful electron and hydrogen ions or as a critical substrate to ensure the proper execution …

There has been an upsurge of interest in the adipocyte coincident with the onset of the
obesity epidemic and the realization that adipose tissue plays a major role in the regulation …

Ageing is a plastic process and can be successfully modulated by some biomedical
approaches or pharmaceutics. In this manner it is possible to delay or even prevent some …