Platinum-based chemotherapies, such as cisplatin, play a large role in cancer treatment.
The development of resistance and treatment toxicity creates substantial barriers to disease …

DNA damage repair plays a key role in maintaining genomic stability and integrity. Flap
endonuclease 1 (FEN1) is a core protein in the base excision repair (BER) pathway and …

Recent studies suggest that B cells could play an important role in the tumor
microenvironment. However, the role of humoral responses in endometrial cancer remains …

The PARP inhibitor (PARPi) olaparib is currently the drug of choice for serous ovarian
cancer (OC), especially in patients with homologous recombination (HR) repair deficiency …

DNA repair targeted therapeutics is a promising precision medicine strategy in cancer. The
development and clinical use of PARP inhibitors has transformed lives for many patients …

Abstract Flap endonuclease 1 (FEN1), a structure-selective endonuclease essential for DNA
replication and repair, has been considered as a new promising marker for early cancer …

Purpose Cholangiocarcinoma (CHOL) comprises a cluster of highly heterogeneous
malignant biliary tumors. Flap endonuclease-1 (FEN1) is a member of the Rad2 structure …

Platinum resistance is a clinical challenge in ovarian cancer. Platinating agents induce DNA
damage which activate Mre11 nuclease directed DNA damage signalling and response …

Rationale: The human ligases (LIG1, LIG3 and LIG4) are essential for the maintenance of
genomic integrity by catalysing the formation of phosphodiester bonds between adjacent …

Abstract Purpose Flap endonuclease 1 (FEN1) is highly upregulated in prostate cancer and
promotes the growth of prostate cancer cells. Androgen receptor (AR) is the most critical …