It is well-established that the chemokine CXC motif ligand 13 (CXCL13) and its receptor, the
G-protein coupled receptor (GPCR) CXCR5, play fundamental roles in inflammatory …

In humans, the glutathione S-transferases (GST) protein family is composed of seven
members that present remarkable structural similarity and some degree of overlapping …

Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of
the most extensively studied signaling kinases. PKCs signal through multiple pathways and …

Abstract The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by
genetic alterations in upstream signaling molecules such as receptor tyrosine kinases …

Diacylglycerol (DAG) is a lipid second messenger that is generated in response to
extracellular stimuli and channels intracellular signals that affect mammalian cell …

Few kinases have been studied as extensively as protein kinase C (PKC), particularly in the
context of cancer. As major cellular targets for the phorbol ester tumor promoters and …

PKCε, an oncogenic member of the PKC family, is aberrantly overexpressed in epithelial
cancers. To date, little is known about functional interactions of PKCε with other genetic …

We present here first time that Plumbagin (PL), a medicinal plant-derived 1, 4-
naphthoquinone, inhibits the growth and metastasis of human prostate cancer (PCa) cells in …

The nuclear transcription factor signal transducer and activator of transcription 3 (Stat3) has
recently been reported to have a localized mitochondrial regulatory function. Current data …

The pro-oncogenic kinase PKCε is overexpressed in human prostate cancer and cooperates
with loss of the tumor suppressor Pten for the development of prostatic adenocarcinoma …