The hedgehog pathway, for which sonic hedgehog (Shh) is the most prominent ligand, is
highly conserved and is tightly associated with embryonic development in a number of …

Simple Summary This literature analysis is focused on the pleiotropic action associated with
metformin treatment. Precisely, metformin treatment exerts many health effects, mainly by …

Abstract Background Prostate cancer (PCa) is characterized as the most frequent type of
cancer in males. Recent research has suggested patients who have diabetes mellitus taking …

Exposure of tumor cells to ionizing radiation (IR) alters the microenvironment, particularly the
fatty acid (FA) profile and activity. Moreover, abnormal FA metabolism, either catabolism or …

This study was designed to investigate the protective effect of resveratrol (RES) on
premature ovarian failure (POF) and the proliferation of female germline stem cells (FGSCs) …

GLI transcription factors have important roles in intracellular signaling cascade, acting as the
main mediators of the HH-GLI signaling pathway. This is one of the major developmental …

Metformin is the most used drug for type 2 diabetes (T2DM). Its antitumor activity has been
described by clinical studies showing reduced risk of cancer development in T2DM patients …

Simple Summary Medulloblastoma is the most common malignant brain tumor in the
pediatric population. Despite the utilization of aggressive treatment modalities, including …

Background: The relationship between metformin use and the risk of prostate cancer is still
inconclusive. Therefore, we performed a systematic review and meta-analysis of all eligible …

Metformin is considered the first-choice drug for type 2 diabetes treatment. Actually,
pleiotropic effects of metformin have been recognized, and there is evidence that this drug …