γ-Secretase: once and future drug target for Alzheimer's disease
MS Wolfe - Expert Opinion on Drug Discovery, 2024 - Taylor & Francis
Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting over 6
million in the US and over 40 million worldwide. 1 The gradual loss of neurons, particularly …
million in the US and over 40 million worldwide. 1 The gradual loss of neurons, particularly …
Chemical and Structural Biology of γ-Secretase and Its Role in Familial Alzheimer's Disease
D Sleem - 2023 - search.proquest.com
Abstract γ-secretase is an intramembrane cleaving protease that conducts hydrolysis within
the lipid bilayer to proteolyze nearly 100 different membrane protein substrates. One …
the lipid bilayer to proteolyze nearly 100 different membrane protein substrates. One …