Genome-wide association studies (GWAS) have provided insights into the genetic basis of
complex diseases. In the next step, integrative multi-omics approaches can characterize …

Systemic lupus erythematosus (SLE) is characterized by immune system dysfunction and is
clinically heterogeneous, exhibiting renal, dermatological, neuropsychiatric, and …

Systemic lupus erythematosus (SLE), a worldwide autoimmune disease with high
heritability, shows differences in prevalence, severity and age of onset among different …

Abstract The HLA-DRB1* 03: 01 allele is a major genetic risk factor in systemic lupus
erythematosus (SLE), but the mechanistic basis of the association is unclear. Here we show …

Systemic lupus erythematosus (SLE) is a prime example of how the interplay between
genetic and environmental factors can trigger systemic autoimmunity, particularly in young …

Recent basic science advances in psoriatic disease (PsD) were presented and discussed at
the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2022 …

Lupus nephritis (LN) is a crucial complication of systemic lupus erythematosus (SLE). IKZF2
was identified as a lupus susceptibility locus, while its exact molecular function in LN is …

Unresolved inflammation fosters and supports a wide range of human pathologies. There is
growing evidence for a role played by cytosolic nucleic acids in initiating and supporting …

Autoimmune rheumatic diseases (ARD) such as systemic lupus erythematosus (SLE),
Sjögren's syndrome (SS), rheumatoid arthritis (RA), systemic sclerosis, and vasculitis are …

Multi-omics approaches hold promise to facilitate the understanding of underlying
mechanisms and facilitate diagnosis and management of many autoimmune conditions …