Genomics of hypertension: the road to precision medicine
S Padmanabhan, AF Dominiczak - Nature Reviews Cardiology, 2021 - nature.com
The known genetic architecture of blood pressure now comprises> 30 genes, with rare
variants resulting in monogenic forms of hypertension or hypotension and> 1,477 common …
variants resulting in monogenic forms of hypertension or hypotension and> 1,477 common …
Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases
E Pretorius, DB Kell - Integrative biology, 2014 - academic.oup.com
Most non-communicable diseases involve inflammatory changes in one or more vascular
systems, and there is considerable evidence that unliganded iron plays major roles in this …
systems, and there is considerable evidence that unliganded iron plays major roles in this …
Explaining models by propagating Shapley values of local components
In healthcare, making the best possible predictions with complex models (eg, neural
networks, ensembles/stacks of different models) can impact patient welfare. In order to make …
networks, ensembles/stacks of different models) can impact patient welfare. In order to make …
Erythrocytosis in the general population: clinical characteristics and association with clonal hematopoiesis
HJCM Wouters, R Mulder, IA van Zeventer… - Blood …, 2020 - ashpublications.org
Erythrocytosis is a common reason for referral to hematology services and is usually
secondary in origin. The aim of this study was to assess clinical characteristics and clonal …
secondary in origin. The aim of this study was to assess clinical characteristics and clonal …
Increasing brain angiotensin converting enzyme 2 activity decreases anxiety-like behavior in male mice by activating central Mas receptors
Over-activation of the brain renin-angiotensin system (RAS) has been implicated in the
etiology of anxiety disorders. Angiotensin converting enzyme 2 (ACE2) inhibits RAS activity …
etiology of anxiety disorders. Angiotensin converting enzyme 2 (ACE2) inhibits RAS activity …
Approach to interpreting common laboratory pathology tests in transgender individuals
Context As the number of transgender (trans) people (including those who are binary and/or
nonbinary identified) seeking gender-affirming hormone therapy rises, endocrinologists are …
nonbinary identified) seeking gender-affirming hormone therapy rises, endocrinologists are …
Transgender health and the impact of aging and menopause
Gender affirming hormone therapy (GAHT) is used by many transgender people to reduce
gender incongruence and improve psychological functioning. As GAHT shares many …
gender incongruence and improve psychological functioning. As GAHT shares many …
Erythrocytosis and polycythemia secondary to testosterone replacement therapy in the aging male
SD Jones Jr, T Dukovac, P Sangkum… - Sexual medicine …, 2015 - academic.oup.com
Introduction Testosterone replacement therapy (TRT) is a common treatment for
hypogonadism in aging males. Men with low to low-normal levels of testosterone have …
hypogonadism in aging males. Men with low to low-normal levels of testosterone have …
Association of hematocrit with blood pressure and hypertension
M Emamian, SM Hasanian, M Tayefi… - Journal of clinical …, 2017 - Wiley Online Library
Background Hypertension (HTN) is a risk factor for stroke, renal failure, and cardiovascular
disease. The association between biochemical and hematological parameters with high …
disease. The association between biochemical and hematological parameters with high …
White blood cell and platelet distribution widths are associated with hypertension: data mining approaches
A Mansoori, NS Farizani Gohari, L Etemad… - Hypertension …, 2024 - nature.com
In this paper, we are going to investigate the association between Hypertension (HTN) and
routine hematologic indices in a cohort of Iranian adults. The data were obtained from a total …
routine hematologic indices in a cohort of Iranian adults. The data were obtained from a total …