Genomics of hypertension: the road to precision medicine

S Padmanabhan, AF Dominiczak - Nature Reviews Cardiology, 2021 - nature.com
The known genetic architecture of blood pressure now comprises> 30 genes, with rare
variants resulting in monogenic forms of hypertension or hypotension and> 1,477 common …

Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases

E Pretorius, DB Kell - Integrative biology, 2014 - academic.oup.com
Most non-communicable diseases involve inflammatory changes in one or more vascular
systems, and there is considerable evidence that unliganded iron plays major roles in this …

Explaining models by propagating Shapley values of local components

H Chen, S Lundberg, SI Lee - Explainable AI in Healthcare and Medicine …, 2021 - Springer
In healthcare, making the best possible predictions with complex models (eg, neural
networks, ensembles/stacks of different models) can impact patient welfare. In order to make …

Erythrocytosis in the general population: clinical characteristics and association with clonal hematopoiesis

HJCM Wouters, R Mulder, IA van Zeventer… - Blood …, 2020 - ashpublications.org
Erythrocytosis is a common reason for referral to hematology services and is usually
secondary in origin. The aim of this study was to assess clinical characteristics and clonal …

Increasing brain angiotensin converting enzyme 2 activity decreases anxiety-like behavior in male mice by activating central Mas receptors

L Wang, AD De Kloet, D Pati, H Hiller, JA Smith… - …, 2016 - Elsevier
Over-activation of the brain renin-angiotensin system (RAS) has been implicated in the
etiology of anxiety disorders. Angiotensin converting enzyme 2 (ACE2) inhibits RAS activity …

Approach to interpreting common laboratory pathology tests in transgender individuals

AS Cheung, HY Lim, T Cook, S Zwickl… - The Journal of …, 2021 - academic.oup.com
Context As the number of transgender (trans) people (including those who are binary and/or
nonbinary identified) seeking gender-affirming hormone therapy rises, endocrinologists are …

Transgender health and the impact of aging and menopause

AS Cheung, BJ Nolan, S Zwickl - Climacteric, 2023 - Taylor & Francis
Gender affirming hormone therapy (GAHT) is used by many transgender people to reduce
gender incongruence and improve psychological functioning. As GAHT shares many …

Erythrocytosis and polycythemia secondary to testosterone replacement therapy in the aging male

SD Jones Jr, T Dukovac, P Sangkum… - Sexual medicine …, 2015 - academic.oup.com
Introduction Testosterone replacement therapy (TRT) is a common treatment for
hypogonadism in aging males. Men with low to low-normal levels of testosterone have …

Association of hematocrit with blood pressure and hypertension

M Emamian, SM Hasanian, M Tayefi… - Journal of clinical …, 2017 - Wiley Online Library
Background Hypertension (HTN) is a risk factor for stroke, renal failure, and cardiovascular
disease. The association between biochemical and hematological parameters with high …

White blood cell and platelet distribution widths are associated with hypertension: data mining approaches

A Mansoori, NS Farizani Gohari, L Etemad… - Hypertension …, 2024 - nature.com
In this paper, we are going to investigate the association between Hypertension (HTN) and
routine hematologic indices in a cohort of Iranian adults. The data were obtained from a total …