Solid dispersions have achieved significant interest as an effective means of enhancing the
dissolution rate and thus the bioavailability of a range of weakly water‐soluble drugs. Solid …

Over the last half-century, solid dispersions (SDs) have been intensively investigated as a
strategy to improve drugs solubility and dissolution rate, enhancing oral bioavailability. In …

The use of proteins such as human serum albumin (HSA) to form nanometric systems seems
very promising since they are non-toxic, biodegradable and have no antigenic activity. This …

Kaempferol (KPF), an important flavonoid, has been reported to exert antioxidant, anti-
inflammatory, and anticancer activity. However, this compound has low water solubility and …

Benznidazole (BZ) tablets are a unique form of treatment available for treating Chagas
disease. Development of a liquid formulation containing BZ easy to administer orally for the …

Chagas disease is a neglected tropical disease affecting the American continent and also
some regions of Europe. Benznidazole, approved by FDA, is a drug of choice but its poor …

Antibiotic resistance has become a global crisis, driving the exploration for novel antibiotics
and novel treatment approaches. Among these research efforts two classes of antibiotics …

This study investigated an agglomeration of nanoparticles in a suspension using nuclear
magnetic resonance (NMR) relaxation. The nanosuspension was prepared by wet bead …

The blood-sucking bug Triatoma infestans is the main Chagas disease vector in the
Southern Cone of Latin America. Populations resistant to pyrethroid insecticides have been …

Chagas disease is a neglected parasitic disease caused by Trypanosoma cruzi, whose
treatment has remained unsatisfactory for over 50 years, given that it is limited to two drugs …