The study of innate immunity and its link to inflammation and host defense encompasses
diverse areas of biology, ranging from genetics and biophysics to signal transduction and …

The identification of actionable tumor antigens is indispensable for the development of
several cancer immunotherapies, including T cell receptor–transduced T cells and patient …

Immune-related adverse events, particularly severe toxicities such as myocarditis, are major
challenges to the utility of immune checkpoint inhibitors (ICIs) in anticancer therapy. The …

Ribosome profiling has revealed pervasive but largely uncharacterized translation outside of
canonical coding sequences (CDSs). In this work, we exploit a systematic CRISPR-based …

Non-coding RNAs do not encode proteins and regulate various oncological processes. They
are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics …

Naive T cells undergo radical changes during the transition from dormant to hyperactive
states upon activation, which necessitates de novo protein production via transcription and …

Next-generation sequencing has provided a more complete picture of the composition of the
human transcriptome indicating that much of the “blueprint” is a vastness of poorly …

Modern genome-scale methods that identify new genes, such as proteogenomics and
ribosome profiling, have revealed, to the surprise of many, that overlap in genes, open …

Non-coding RNAs (ncRNAs) are unique RNA transcripts that have been widely identified in
the eukaryotic genome and have been shown to play key roles in the development of many …

The recent success of cancer immunotherapies has highlighted the benefit of harnessing the
immune system for cancer treatment. Vaccines have a long history of promoting immunity to …