The brain operates through the synaptic interaction of distant neurons within flexible, often
heterogeneous, distributed systems. Histological studies have detailed the connections …

Multiple sclerosis (MS) is a neurological disorder affecting the central nervous system and
features extensive functional brain changes that are poorly understood but relate strongly to …

Importance Cognitive impairment is a common and disabling feature of multiple sclerosis
(MS), but a precise characterization of cognitive phenotypes in patients with MS is lacking …

Multiple sclerosis is a neuroinflammatory and neurodegenerative disorder of the central
nervous system that can be considered a network disorder. In MS, lesional pathology …

The relationship between structural and functional brain networks has been characterised
as complex: the two networks mirror each other and show mutual influence but they also …

Childhood trauma is a leading risk factor for adolescents developing major depressive
disorder (MDD); however, the underlying neuroimaging mechanisms remain unclear. This …

Background Available criteria for cognitive phenotypes in multiple sclerosis (MS) do not
consider the severity of impairment. Objectives To identify cognitive phenotypes with varying …

Cognitive impairment is a frequent and meaningful symptom in multiple sclerosis (MS),
caused by the accrual of brain structural damage only partially counteracted by effective …

Cognitive impairment (CI) occurs in 43 to 70% of multiple sclerosis (MS) patients at both
early and later disease stages. Cognitive domains typically involved in MS include attention …

Cognitive impairment is common in people with multiple sclerosis and strongly affects their
daily functioning. Reports have linked disturbed cognitive functioning in multiple sclerosis to …