Anticancer drugs: recent strategies to improve stability profile, pharmacokinetic and pharmacodynamic properties

G Ioele, M Chieffallo, MA Occhiuzzi, M De Luca… - Molecules, 2022 - mdpi.com
In past decades, anticancer research has led to remarkable results despite many of the
approved drugs still being characterized by high systemic toxicity mainly due to the lack of …

[HTML][HTML] Liposome-polymer complex for drug delivery system and vaccine stabilization

AK Umar, N Wathoni, JH Zothantluanga, S Das… - Heliyon, 2022 - cell.com
Liposomes have been used extensively as micro-and nanocarriers for hydrophobic or
hydrophilic molecules. However, conventional liposomes are biodegradable and quickly …

Novel findings for quercetin encapsulation and preservation with cyclodextrins, liposomes, and drug-in-cyclodextrin-in-liposomes

J Azzi, A Jraij, L Auezova, S Fourmentin… - Food …, 2018 - Elsevier
The low solubility, poor bioavailability, and low chemical stability of quercetin (Quer) are the
main drawbacks that limit its use as a food nutraceutical. In this study, the encapsulation in …

1, 4-Dihydropyridine antihypertensive drugs: Recent advances in photostabilization strategies

M De Luca, G Ioele, G Ragno - Pharmaceutics, 2019 - mdpi.com
The 1, 4-dihydropyridine (DHP) drugs are nowadays the most used drugs in the treatment of
hypertension. However, all the structures in this series present a significant sensitivity to …

First evaluation of drug-in-cyclodextrin-in-liposomes as an encapsulating system for nerolidol

J Azzi, L Auezova, PE Danjou, S Fourmentin… - Food chemistry, 2018 - Elsevier
Nerolidol, a naturally occurring sesquiterpene with antimicrobial activities, is a promising
candidate as a natural alternative for synthetic preservatives in food. However, its …

Photosensitive drugs: A review on their photoprotection by liposomes and cyclodextrins

G Ioele, M De Luca, A Garofalo, G Ragno - Drug Delivery, 2017 - Taylor & Francis
Nowadays, an exciting challenge in the drug chemistry and technology research is
represented by the development of methods aimed to protect molecular integrity and …

Complex systems that incorporate cyclodextrins to get materials for some specific applications

MA Fernández, OF Silva, RV Vico, RH de Rossi - Carbohydrate research, 2019 - Elsevier
Cyclodextrins (CDs) are a family of biodegradable cyclic hydrocarbons composed of α-(1, 4)
linked glucopyranose subunits, the more common containing 6, 7 or 8 glucose units are …

Photostability issues in pharmaceutical dosage forms and photostabilization

KY Janga, T King, N Ji, S Sarabu, G Shadambikar… - AAPS …, 2018 - Springer
Photodegradation is one of the major pathways of the degradation of drugs. Some
therapeutic agents and excipients are highly sensitive to light and undergo significant …

Photodegradation of anti-inflammatory drugs: Stability tests and lipid nanocarriers for their photoprotection

G Ioele, F Grande, M De Luca, MA Occhiuzzi… - Molecules, 2021 - mdpi.com
The present paper provides an updated overview of the methodologies applied in
photodegradation studies of non-steroidal anti-inflammatory drugs. Photostability tests …

Nanoplatform Based Intranasal Vaccines: Current Progress and Clinical Challenges

Z Bai, D Wan, T Lan, W Hong, H Dong, Y Wei, X Wei - ACS nano, 2024 - ACS Publications
Multiple vaccine platforms have been employed to develop the nasal SARS-CoV-2 vaccines
in preclinical studies, and the dominating pipelines are viral vectored as protein-based …