Keratohyalin granules were discovered in the mid-19th century in cells that terminally
differentiate to form the outer, cornified layer of the epidermis. The first indications of the …

Ichthyosis covers a wide spectrum of diseases affecting the cornification of the skin. In recent
years, new advances in understanding the pathophysiology of ichthyosis have been made …

Background The ichthyoses are rare genetic disorders associated with generalized scaling,
erythema, and epidermal barrier impairment. Pathogenesis-based therapy is largely lacking …

The epidermis is a barrier that prevents water loss while keeping harmful substances from
penetrating the host. The impermeable cornified layer of the stratum corneum is maintained …

Epidermal barrier integrity could be influenced by various factors involved in epidermal cell
differentiation and proliferation, cell–cell adhesion, and skin lipids. Dysfunction of this barrier …

Background Ichthyoses are a group of rare skin disorders lacking effective treatments.
Although genetic mutations are progressively delineated, comprehensive molecular …

Background: Activation of protease-activated receptor-2 (PAR2) has been implicated in
inflammation, pruritus, and skin barrier regulation, all characteristics of atopic dermatitis …

Atopic diseases, including atopic dermatitis (AD) and asthma, affect a large proportion of the
population, with increasing prevalence worldwide. AD often precedes the development of …

As the outermost layer of the skin, the epidermis is playing a major role in organism
homeostasis providing the first barrier against external aggressions. Although considered as …

Skin appearance is essential for self‐esteem and quality of life; consequently, skin care
products represent a huge market. In particular, cosmeceuticals constitute a hybrid category …