Prion diseases range from being highly infectious, for example scrapie and CWD which
show facile transmission between susceptible individuals, to showing negligible horizontal …

The ability of abnormal TSE-associated forms of PrP to seed the formation of amyloid fibrils
from recombinant PrPSen has served as the basis for several relatively rapid and highly …

A major problem for the effective diagnosis and management of prion diseases is the lack of
rapid high-throughput assays to measure low levels of prions. Such measurements have …

ABSTRACT A key challenge in managing transmissible spongiform encephalopathies
(TSEs) or prion diseases in medicine, agriculture, and wildlife biology is the development of …

The horizontal transmission of prion diseases has been well characterized in bovine
spongiform encephalopathy (BSE), chronic wasting disease (CWD) of deer and elk and …

Blood-borne transmission of infectious prions during the symptomatic and asymptomatic
stages of disease occurs for both human and animal transmissible spongiform …

The development of variant Creutzfeldt-Jakob disease (vCJD) in three recipients of non-
leukoreduced red blood cells from asymptomatic donors who subsequently developed the …

In sheep, scrapie is a fatal neurologic disease that is caused by a misfolded protein called a
prion (designated PrP Sc). The normal cellular prion protein (PrP C) is encoded by an …

Prion diseases are transmissible neurodegenerative diseases affecting humans and
animals. The agent of the disease is the prion consisting mainly, if not solely, of a misfolded …

A growing number of diseases are being linked to protein misfolding and amyloid formation.
Recently, p53 was also shown to associate into amyloid aggregates, raising the question of …