Extracellular vesicles: A bright star of nanomedicine

P Wu, B Zhang, DKW Ocansey, W Xu, H Qian - Biomaterials, 2021 - Elsevier
Extracellular vesicles (EVs) have unique structural, compositional, and morphological
characteristics as well as predominant physiochemical stability and biocompatibility …

Apoptotic bodies for advanced drug delivery and therapy

M Zhou, YJ Li, YC Tang, XY Hao, WJ Xu… - Journal of Controlled …, 2022 - Elsevier
Extracellular vesicles (EVs) have emerged as promising candidates for multiple biomedical
applications. Major types of EVs include exosomes, microvesicles, and apoptotic bodies …

Research progress on dendritic cell vaccines in cancer immunotherapy

J Yu, H Sun, W Cao, Y Song, Z Jiang - Experimental hematology & …, 2022 - Springer
Dendritic cell (DC) vaccines induce specific immune responses that can selectively
eliminate target cells. In recent years, many studies have been conducted to explore DC …

Apoptotic bodies: bioactive treasure left behind by the dying cells with robust diagnostic and therapeutic application potentials

L Yu, G Zhu, Z Zhang, Y Yu, L Zeng, Z Xu… - Journal of …, 2023 - Springer
Apoptosis, a form of programmed cell death, is essential for growth and tissue homeostasis.
Apoptotic bodies (ApoBDs) are a form of extracellular vesicles (EVs) released by dying cells …

In vivo monocyte/macrophage-hitchhiked intratumoral accumulation of nanomedicines for enhanced tumor therapy

L Zheng, X Hu, H Wu, L Mo, S Xie, J Li… - Journal of the …, 2019 - ACS Publications
The inner region of solid tumors is found to be high-pressure, hypoxic, and
immunosuppressive, providing a breeding ground for tumor aggressiveness and metastasis …

Transvascular transport of nanocarriers for tumor delivery

X Li, Y Hu, X Zhang, X Shi, WJ Parak, A Pich - Nature Communications, 2024 - nature.com
Nanocarriers (NCs) play a crucial role in delivering theranostic agents to tumors, making
them a pivotal focus of research. However, the persistently low delivery efficiency of …

Immunotherapy in acute myeloid leukemia and myelodysplastic syndromes: The dawn of a new era?

Y Liu, JP Bewersdorf, M Stahl, AM Zeidan - Blood reviews, 2019 - Elsevier
Immunotherapy has revolutionized therapy in both solid and liquid malignancies. The ability
to cure acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) with an …

Unleashing the therapeutic potential of apoptotic bodies

TK Phan, DC Ozkocak, IKH Poon - Biochemical society …, 2020 - portlandpress.com
Extracellular vesicles (EVs), membrane-bound vesicles that are naturally released by cells,
have emerged as new therapeutic opportunities. EVs, particularly exosomes and …

Immune dysfunctions and immune-based therapeutic interventions in chronic lymphocytic leukemia

V Griggio, F Perutelli, C Salvetti, E Boccellato… - Frontiers in …, 2020 - frontiersin.org
Chronic lymphocytic leukemia (CLL) is a B-cell malignancy characterized by a wide range of
tumor-induced alterations, which affect both the innate and adaptive arms of the immune …

Trial watch: Dendritic cell-based interventions for cancer therapy

L Galluzzi, L Senovilla, E Vacchelli, A Eggermont… - …, 2012 - Taylor & Francis
Dendritic cells (DCs) occupy a central position in the immune system, orchestrating a wide
repertoire of responses that span from the development of self-tolerance to the elicitation of …