The last decade has been somewhat of a renaissance period for the field of macrophage
biology. This renewed interest, combined with the advent of new technologies and …

Immunodeficient mice engrafted with functional human cells and tissues, that is, humanized
mice, have become increasingly important as small, preclinical animal models for the study …

Abstract Coronavirus disease 2019 (COVID-19) is an infectious disease that can present as
an uncontrolled, hyperactive immune response, causing severe immunological injury …

Programs defining tissue-resident macrophage identity depend on local environmental
cues. For alveolar macrophages (AMs), these signals are provided by immune and …

The study of human macrophages and their ontogeny is an important unresolved issue.
Here, we use a humanized mouse model expressing human cytokines to dissect the …

The molecular and cellular mechanisms that underlie the many roles of macrophages in
health and disease states in vivo remain poorly understood. The purpose of this Review is to …

Tissue-resident macrophages can develop from circulating adult monocytes or from primitive
yolk sac–derived macrophages. The precise ontogeny of alveolar macrophages (AMFs) is …

Immunotherapy is revolutionizing cancer treatment; however, complete responses are
achieved in only a small fraction of patients and tumor types. Thus, there is an urgent need …

Alveolar macrophages are the most abundant innate immune cells in the distal lung
parenchyma, located on the luminal surface of the alveolar space. They are the first to …

The cytokine storm has captured the attention of the public and the scientific community
alike, and while the general notion of an excessive or uncontrolled release of …