[HTML][HTML] Covid-19: perspectives on innate immune evasion
The ongoing outbreak of Coronavirus disease 2019 infection achieved pandemic status on
March 11, 2020. As of September 8, 2020 it has caused over 890,000 mortalities world-wide …
March 11, 2020. As of September 8, 2020 it has caused over 890,000 mortalities world-wide …
Immunoregulation with mTOR inhibitors to prevent COVID‐19 severity: A novel intervention strategy beyond vaccines and specific antiviral medicines
Y Zheng, R Li, S Liu - Journal of medical virology, 2020 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) has become a major global public health
concern. The mortality rate for critically ill patients is up to 60%, and, thus, reducing the …
concern. The mortality rate for critically ill patients is up to 60%, and, thus, reducing the …
[HTML][HTML] Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with a
382-nucleotide deletion (∆ 382) in the open reading frame 8 (ORF8) region of the genome …
382-nucleotide deletion (∆ 382) in the open reading frame 8 (ORF8) region of the genome …
Neutralizing antibodies correlate with protection from SARS-CoV-2 in humans during a fishery vessel outbreak with a high attack rate
A Addetia, KHD Crawford, A Dingens… - Journal of clinical …, 2020 - Am Soc Microbiol
The development of vaccines against SARS-CoV-2 would be greatly facilitated by the
identification of immunological correlates of protection in humans. However, to date, studies …
identification of immunological correlates of protection in humans. However, to date, studies …
[HTML][HTML] The coding capacity of SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing
coronavirus disease 2019 (COVID-19) pandemic 1. To understand the pathogenicity and …
coronavirus disease 2019 (COVID-19) pandemic 1. To understand the pathogenicity and …
Discovery and genomic characterization of a 382-nucleotide deletion in ORF7b and ORF8 during the early evolution of SARS-CoV-2
To date, limited genetic changes in the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) genome have been described. Here, we report a 382-nucleotide (nt) deletion …
(SARS-CoV-2) genome have been described. Here, we report a 382-nucleotide (nt) deletion …
Architecture and self‐assembly of the SARS‐CoV‐2 nucleocapsid protein
Q Ye, AMV West, S Silletti, KD Corbett - Protein Science, 2020 - Wiley Online Library
The COVID‐2019 pandemic is the most severe acute public health threat of the twenty‐first
century. To properly address this crisis with both robust testing and novel treatments, we …
century. To properly address this crisis with both robust testing and novel treatments, we …
[HTML][HTML] SARS-CoV-2 ORF3b is a potent interferon antagonist whose activity is increased by a naturally occurring elongation variant
Y Konno, I Kimura, K Uriu, M Fukushi, T Irie… - Cell reports, 2020 - cell.com
One of the features distinguishing SARS-CoV-2 from its more pathogenic counterpart SARS-
CoV is the presence of premature stop codons in its ORF3b gene. Here, we show that SARS …
CoV is the presence of premature stop codons in its ORF3b gene. Here, we show that SARS …
[HTML][HTML] COVID-19 survival associates with the immunoglobulin response to the SARS-CoV-2 spike receptor binding domain
M Secchi, E Bazzigaluppi, C Brigatti… - The Journal of …, 2020 - Am Soc Clin Investig
BACKGROUND Serological assays are of critical importance to investigate correlates of
response and protection in coronavirus disease 2019 (COVID-19), to define previous …
response and protection in coronavirus disease 2019 (COVID-19), to define previous …
[HTML][HTML] Neutralizing antibody against SARS-CoV-2 spike in COVID-19 patients, health care workers, and convalescent plasma donors
Rapid and specific antibody testing is crucial for improved understanding, control, and
treatment of COVID-19 pathogenesis. Herein, we describe and apply a rapid, sensitive, and …
treatment of COVID-19 pathogenesis. Herein, we describe and apply a rapid, sensitive, and …