Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca2+-
permeable component of excitatory neurotransmission in the central nervous system (CNS) …

Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …

Neural stem cells (NSCs), with the capability of self‐renewal, differentiation, and
environment modulation, are considered promising for stroke, brain injury therapy, and …

Nearly sixty years ago Fredrich Timm developed a histochemical technique that revealed a
rich reserve of free zinc in distinct regions of the brain. Subsequent electron microscopy …

N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key role in brain development and …

Significance: Essential metals such as copper, iron, manganese, and zinc play a role as
cofactors in the activity of a wide range of processes involved in cellular homeostasis and …

NMDA-type glutamate receptors are ligand-gated ion channels that mediate a major
component of excitatory neurotransmission in the central nervous system (CNS). They are …

Abstract Zinc transporter 3 (ZnT3) is the sole mechanism responsible for concentrating zinc
ions within synaptic vesicles in a subset of the brain's glutamatergic neurons. This vesicular …

The recent emergence of signaling roles for transition metals presages a broader
contribution of these elements beyond their traditional functions as metabolic cofactors. New …