[HTML][HTML] Extrachromosomal circular DNA in cancer: history, current knowledge, and methods
Extrachromosomal circular DNA (eccDNA) is a closed-circle, nuclear, nonplasmid DNA
molecule found in all tested eukaryotes. eccDNA plays important roles in cancer …
molecule found in all tested eukaryotes. eccDNA plays important roles in cancer …
Extrachromosomal oncogene amplification in tumour pathogenesis and evolution
Recent reports have demonstrated that oncogene amplification on extrachromosomal DNA
(ecDNA) is a frequent event in cancer, providing new momentum to explore a phenomenon …
(ecDNA) is a frequent event in cancer, providing new momentum to explore a phenomenon …
[HTML][HTML] ERα-associated translocations underlie oncogene amplifications in breast cancer
Focal copy-number amplification is an oncogenic event. Although recent studies have
revealed the complex structure,–and the evolutionary trajectories of oncogene amplicons …
revealed the complex structure,–and the evolutionary trajectories of oncogene amplicons …
Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH
Extrachromosomal DNA (ecDNA) is a common mode of oncogene amplification but is
challenging to analyze. Here, we adapt CRISPR-CATCH, in vitro CRISPR-Cas9 treatment …
challenging to analyze. Here, we adapt CRISPR-CATCH, in vitro CRISPR-Cas9 treatment …
Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences
Tumour cells release an abundance of microvesicles containing a selected set of proteins
and RNAs. Here, we show that tumour microvesicles also carry DNA, which reflects the …
and RNAs. Here, we show that tumour microvesicles also carry DNA, which reflects the …
Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma
Circular extrachromosomal DNA (ecDNA) in patient tumors is an important driver of
oncogenic gene expression, evolution of drug resistance and poor patient outcomes …
oncogenic gene expression, evolution of drug resistance and poor patient outcomes …
TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome
FG Rücker, RF Schlenk, L Bullinger… - Blood, The Journal …, 2012 - ashpublications.org
To assess the frequency of TP53 alterations and their correlation with other genetic changes
and outcome in acute myeloid leukemia with complex karyotype (CK-AML), we performed …
and outcome in acute myeloid leukemia with complex karyotype (CK-AML), we performed …
The genomic and spatial mobility of extrachromosomal DNA and its implications for cancer therapy
E van Leen, L Brückner, AG Henssen - Nature genetics, 2022 - nature.com
Extrachromosomal DNA (ecDNA) amplification has been observed in at least 30 different
cancer types and is associated with worse patient outcomes. This has been linked to …
cancer types and is associated with worse patient outcomes. This has been linked to …
Myc roles in hematopoiesis and leukemia
MD Delgado, J León - Genes & cancer, 2010 - journals.sagepub.com
Hematopoiesis is a process capable of generating millions of cells every second, as
distributed in many cell types. The process is regulated by a number of transcription factors …
distributed in many cell types. The process is regulated by a number of transcription factors …
[HTML][HTML] Classification of extrachromosomal circular DNA with a focus on the role of extrachromosomal DNA (ecDNA) in tumor heterogeneity and progression
Z Liao, W Jiang, L Ye, T Li, X Yu, L Liu - Biochimica et Biophysica Acta (BBA …, 2020 - Elsevier
Although the eukaryotic genome is mainly comprised of linear chromosomal DNA, genes
can also be found outside of chromosomes. The unconventional presence of …
can also be found outside of chromosomes. The unconventional presence of …