Natural catalytic antibodies in norm, autoimmune, viral, and bacterial diseases

GA Nevinsky, VN Buneva - The Scientific World Journal, 2010 - Wiley Online Library
In human patients with autoimmune, viral, and bacterial diseases, the generation of
antibodies (Abs) to foreign antigens and/or autoantibodies to self‐antigens usually occurs …

Catalytic antibodies: Design, expression, and their applications in medicine

D Zhao, J Chen, X Hu, S Zhang - Applied Biochemistry and Biotechnology, 2023 - Springer
Catalytic antibodies made it feasible to develop new catalysts, which had previously been
the subject of research. Scientists have discovered natural antibodies that can hydrolyze …

Recognition and degradation of myelin basic protein peptides by serum autoantibodies: novel biomarker for multiple sclerosis

AA Belogurov, IN Kurkova, A Friboulet… - The journal of …, 2008 - journals.aai.org
The pathologic role of autoantibodies in autoimmune disease is widely accepted. Recently,
we reported that anti-myelin basic protein (MBP) serum Abs from multiple sclerosis (MS) …

Do proteolytic antibodies complete the panoply of the autoimmune response in acquired haemophilia A?

A Mahendra, S Padiolleau‐Lefevre… - British journal of …, 2012 - Wiley Online Library
Acquired haemophilia A (AHA) is a rare bleeding disorder characterized by the sudden
generation of autoantibodies against factor VIII (FVIII) in individuals with no previous history …

IgG‐Dependent Dismutation of Superoxide in Patients with Different Types of Multiple Sclerosis and Healthy Subjects

LP Smirnova, IA Mednova, NM Krotenko… - Oxidative medicine …, 2020 - Wiley Online Library
This work is the first to demonstrate that class G immunoglobulins (IgGs) in patients with
multiple sclerosis and healthy individuals have the ability to catalyze the dismutation …

Idiotypic networks: toward a renaissance?

U Behn - Immunological reviews, 2007 - Wiley Online Library
Idiotypic networks, after being a dominating paradigm for more than a decade, have fallen
out of fashion in parallel with the rapid success of molecular immunobiology. Today signs of …

Natural Antibodies Produced in Vaccinated Patients and COVID-19 Convalescents Hydrolyze Recombinant RBD and Nucleocapsid (N) Proteins

AM Timofeeva, LS Shayakhmetova, AO Nikitin… - Biomedicines, 2024 - mdpi.com
Antibodies are protein molecules whose primary function is to recognize antigens. However,
recent studies have demonstrated their ability to hydrolyze specific substrates, such as …

Losac, the first hemolin that exhibits procogulant activity through selective factor X proteolytic activation

MP Alvarez-Flores, D Furlin, OHP Ramos… - Journal of Biological …, 2011 - ASBMB
Envenoming by the contact of human skin with Lonomia obliqua caterpillars promotes a
hemorrhagic syndrome characterized by a consumptive coagulopathy. Losac (Lonomia …

A human germ line antibody light chain with hydrolytic properties associated with multimerization status

V Sharma, W Heriot, K Trisler, V Smider - Journal of Biological Chemistry, 2009 - ASBMB
Antibodies with nucleophilic or catalytic properties often have these characteristics encoded
in their germ line genes. Because hydrolytic activity has been reported to be associated with …

The effect of postpartum vitamin A supplementation on breast milk immune regulators and infant immune functions: study protocol of a randomized, controlled trial

SM Ahmad, MI Hossain, P Bergman, Y Kabir, R Raqib - Trials, 2015 - Springer
Background Because of limited impact on infant morbidity, mortality, and vitamin A status,
the new guideline of the World Health Organization (WHO) does not recommend postpartum …